Progressive supranuclear palsy (Steele et al.) has a characteristic pattern of dementia: (1) forgetfulness, (2) slowing of thought processes, (3) emotional or personality changes (apathy or depression with occasional outbursts of irritability), and (4) impaired ability to manipulate acquired knowledge. In many neurological disease states associated with subcortical pathology a similar pattern of dementia exists. The neurobehavioural changes of progressive supranuclear palsy thus typify a clinical pattern which may be referred to as subcortical dementia. The subcortical dementias have a striking clinical resemblance to the dementia which occurs after bifrontal lobe disease. However, the subcortical dementias can be clearly distinguished clinically from cortical dementias, other than frontal dementias. We propose as a tentative hypothesis that there may be common pathophysiological mechanisms underlying the subcortical dementias-in particular, disturbances of timing and activation. There are immediate practical implications of this hypothesis: drugs which have an effect on subcortical timing and activating mechanisms may be useful in the treatment of subcortical dementias.
A syndrome of paralysis of downward gaze, dysarthria, pseubulbar palsy, axial rigidity of neck and trunk and dementia
Degeneration of the brain stem reticular formation, other parts of the brain stem and the cerebellum; an example of heterogenous systemic degeneration of the central nervous system
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA
Motor programming is more affected in progressive supranuclear palsy than in Parkinson's disease: a spatiotemporal study of event-related desynchronization
Dementia in Parkinson's disease: biochemical evidence for cortical involvement using the immunodetection of abnormal Tau proteins
Atrophy of the corpus callosum, cognitive impairment, and cortical hypometabolism in progressive supranuclear palsy
Neuropsychiatric assessment of Gilles de la Tourette patients: comparative study with other hyperkinetic and hypokinetic movement disorders
Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement
Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: a quantitative analysis of six cases
The Dementia Rating Scale in Alzheimer's disease, Huntington's disease and progressive supranuclear palsy
Comparative assessment of the disorders of higher brain functions in various types of cerebral atrophy
Progressive neuropsychological and extrapyramidal deterioration resembling progressive supranuclear palsy: is aphasia relevant for correct diagnosis?
Category-specific deficits for grammatical classes of words: evidence for possible anatomical correlates
Cholinergic cortical circuits in Parkinson's disease and in progressive supranuclear palsy: a transcranial magnetic stimulation study
EEG changes in subcortical dementia: a study of 22 patients with Steele-Richardson-Olszewski (SRO) syndrome
Performances of multiple sclerosis patients in tasks requiring language and visuoconstruction. Assessment of outpatients in quiescent disease stages
Retrieval from semantic memory may be normal in multiple sclerosis patients: a study of free word association
Metachromatic leukodystrophy and age: a comparative study of clinical, enzymological and ultrastructural findings
Neurological complications of infection with human immunodeficiency virus type 1. A review of literature and 241 cases
Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging
Clinical and pathological study of two patients with progressive supranuclear palsy and Alzheimer's changes. Antigenic determinants that distinguish cortical and subcortical neurofibrillary tangles
A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in marmosets
Subcortical dysfunction in schizophrenia: a comparison with Parkinson's disease and Huntington's disease
Depressive symptoms account for deficient information processing speed but not for impaired working memory in early phase multiple sclerosis (MS)
Analysis of cerebral blood flow of subcortical vascular dementia with single photon emission computed tomography: adaptation of statistical parametric mapping
Regional quantitative analysis of tau-positive neurons in progressive supranuclear palsy: comparison with Alzheimer's disease
Striatal dopaminergic transmission and neocortical glucose utilization in Alzheimer's disease: a triple-tracer positron emission tomography study
Cutaneous sympathetic function and cardiovascular function in patients with progressive supranuclear palsy and Parkinson's disease
Akinesia and axial rigidity without limb rigidity: an intermediate form between progressive supranuclear palsy and pure akinesia of Imai and Narabayashi
Neuropsychological deficits in tests of executive function in asymptomatic and symptomatic HIV-1 seropositive men
The anatomy of melancholia: does frontal-subcortical pathophysiology underpin its psychomotor and cognitive manifestations?
Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance
Cognitive flexibility and complex integration in Parkinson's disease, Huntington's disease, and schizophrenia
Are frontotemporal lobar degeneration, progressive supranuclear palsy and corticobasal degeneration distinct diseases?
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-1986. A 76-year-old woman with a progressive neurologic disorder of 12 years' duration
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 46-1993. A 75-year-old man with right-sided rigidity, dysarthria, and abnormal gait
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1997. A 64-year-old man with progressive dementia, seizures, and unstable gait
Evaluation of information-processing speed and neuropsychological functioning in patients with myotonic dystrophy
Are all subcortical dementias alike? Verbal learning and memory in Parkinson's and Huntington's disease patients
Differences between multi-infarct dementia and Alzheimer's disease on unstructured neuropsychological tasks
Verbal memory performance of patients with human immunodeficiency virus infection: evidence of subcortical dysfunction. The HNRC Group
Episodic and semantic memory in Alzheimer's disease and progressive supranuclear palsy: a comparative study
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology
Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testing
Cognitive and behavioral aspects of PSP since Steele, Richardson and Olszewski's description of PSP 40 years ago and Albert's delineation of the subcortical dementia 30 years ago
Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia
MS vs. HD: can white matter and subcortical gray matter pathology be distinguished neuropsychologically?
Decreased homovanilic acid in cerebrospinal fluid correlates with impaired neuropsychologic function in HIV-1-infected patients
Walking exercise and improved neuropsychological functioning in elderly patients with cardiac disease
Progressive supranuclear palsy combined with Alzheimer's disease: a clinicopathological study of two autopsy cases
Clinical heterogeneity in progressive supranuclear palsy: problems of clinical diagnostic criteria of NINDS-SPSP in a retrospective study of seven Japanese autopsy cases
Assessment of 'subcortical dementia' in patients with Huntington's disease, Parkinson's disease, multiple sclerosis and AIDS by a neuropsychological screening battery
Kufs' disease presenting as progressive dementia with late-onset generalized seizures: a clinicopathological and electrophysiological study
Exaggerated responsiveness to thyrotrophin releasing hormone: a risk factor in women with coronary artery disease
Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study
Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction
Initial letter and semantic category fluency in Alzheimer's disease, Huntington's disease, and progressive supranuclear palsy
Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data
Dementia in two histologically confirmed cases of multiple sclerosis: one case with isolated dementia and one case associated with psychiatric symptoms
Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia
Brain muscarinic receptors in progressive supranuclear palsy and Parkinson's disease: a positron emission tomographic study
Impaired ideomotor limb apraxia in cortical and subcortical dementia: a comparison of Alzheimer's and Huntington's disease
Phenomenology and management of cognitive and behavioral disorders in Parkinson's disease. Rise and logic of dementia in Parkinson's disease
Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study
Longitudinal study of carbon monoxide intoxication by diffusion tensor imaging with neuropsychiatric correlation
Selective speech motor, syntax and cognitive deficits associated with bilateral damage to the putamen and the head of the caudate nucleus: a case study
Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type
Delayed response tasks and prefrontal lesions in man--evidence for self generated patterns of behaviour with poor environmental modulation
Diagnosis of dementia in cancer patients. Cognitive impairment in these patients can go unrecognized
Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis
Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia
Differentiating progressive supranuclear palsy from Parkinson's disease by MRI-based dynamic cerebrospinal fluid flow
Cortical atrophy differentiates Richardson's syndrome from the parkinsonian form of progressive supranuclear palsy
Comparison of regional cerebral blood flow in two subsets of subcortical ischemic vascular dementia: statistical parametric mapping analysis of SPECT
Alzheimer's Disease: Prototype of Cognitive Deterioration, Valuable Lessons to Understand Human Cognition
Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS)
Measures of cognitive and emotional changes in multiple sclerosis and underlying models of brain dysfunction
Comparative study by computerized EEG of dementia of the ALzheimer type and Parkinson's disease with dementia
Cognitive-behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia
Dementias that present with and without posterior cortical features: an important clinical distinction
Neural correlates of cognitive dysfunction in Lewy body diseases and tauopathies: combined assessment with FDG-PET and the CERAD test battery
Utility of Frontal Assessment Battery in detection of neuropsychological dysfunction in Richardson variant of progressive supranuclear palsy
Why do patients with neurodegenerative frontal syndrome fail to answer: 'In what way are an orange and a banana alike?'
Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan
Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations
Progressive supranuclear palsy in a sample of Brazilian population: clinical features of 16 patients
Stepwise comparative status analysis (STEP): a tool for identification of regional brain syndromes in dementia
Progressive supranuclear palsy with agitation: response to trazodone but not to thiothixine or carbamazepine
Neuropsychological impairment in multiple sclerosis patients: the role of (juxta)cortical lesion on FLAIR
Alterations of the cerebral cortex in sporadic small vessel disease: A systematic review of in vivo MRI data
Intellectual impairment and cerebral lesions in multiple cerebral infarcts. A clinical-computed tomography study
Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's disease--a rCBF scintigraphy study
Long-term exercise training for an individual with mixed corticobasal degeneration and progressive supranuclear palsy features: 10-year case report follow-up
Extrapyramidal signs, primitive reflexes and frontal lobe function in senile dementia of the Alzheimer type
The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds
Severity and specificity of cognitive impairment in Alzheimer's, Huntington's, and Parkinson's diseases and progressive supranuclear palsy
Comparison study of executive functions in Parkinson's disease and degenerative cerebellar disease's patients
Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration
Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism
Improvement in word-fluency performance in patients with multiple sclerosis by electromagnetic fields
Tomographic measurements of regional cerebral blood flow in progressive supranuclear palsy and Parkinson's disease
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