PMID: 6979054Jan 1, 1982Paper

The substrates for lateral hypothalamic and medial pre-frontal cortex self-stimulation have different refractory periods and show poor spatial summation

Physiology & Behavior
S Schenk, P Shizgal

Abstract

Refractory periods of the substrates for lateral hypothalamic (LH) and medial pre-frontal cortex (MPFC) self-stimulation were behaviorally estimated. The beginning of recovery from refractoriness was estimated as the time at which recovery was 20% complete. In all 7 rats, this estimate differed substantially across sites, averaging 0.66 msec and 1.59 msec for the LH and MPFC substrates, respectively. The recovery of excitability approached asymptote later in the MPFC substrate (3.5 msec) than in the LH substrate (1.5 msec). These findings are consistent with the view that different fibers subserve the reinforcing consequences of LH and MPFC stimulation. This notion is strengthened by the observation that the rewarding effects of stimulation summated poorly when stimulating pulses were concurrently delivered to these two sites.

References

Aug 1, 1977·Journal of Comparative and Physiological Psychology·G Matthews
May 1, 1979·Physiology & Behavior·J S Yeomans
Dec 1, 1978·Journal of Comparative and Physiological Psychology·C R Gallistel
May 1, 1971·Journal of Comparative and Physiological Psychology·A Routtenberg
Apr 1, 1980·Journal of Comparative and Physiological Psychology·P ShizgalJ Yeomans
May 1, 1980·Physiology & Behavior·W J Mundl

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Citations

Jan 1, 1986·Physiology & Behavior·P A Mason, P M Milner
Jan 1, 1987·Physiology & Behavior·E Miliaressis, J Malette
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·C H West, R P Michael
May 1, 1987·Pharmacology, Biochemistry, and Behavior·A Arregui-AguirreI Morgado-Bernal
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·C L Duvauchelle, A Ettenberg
Sep 1, 1985·Behavioural Brain Research·C Bielajew, G Fouriezos
Mar 1, 1987·Behavioural Brain Research·P P Rompré, E Miliaressis
Mar 31, 1994·Behavioural Brain Research·C Bielajew, M Trzcińska
Feb 28, 1994·Behavioural Brain Research·M P Vachon, E Miliaressis
Feb 1, 1984·Brain Research Bulletin·R A Wise, M A Bozarth
Aug 29, 1991·Behavioural Brain Research·F KaneE Miliaressis
Jan 11, 2000·Behavioural Brain Research·A ArvanitogiannisP Shizgal
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·N M White, N Hiroi
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·A Robertson
Oct 29, 2005·The Journal of Comparative Neurology·Roy A Wise
Jan 20, 2005·Reviews in the Neurosciences·Anne T M Konkle, Catherine Bielajew

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