The Success Story of LDL Cholesterol Lowering

Circulation Research
Terje R Pedersen

Abstract

We can look back at >100 years of cholesterol research that has brought medicine to a stage where people at risk of severe or fatal coronary heart disease have a much better prognosis than before. This progress has not come about without resistance. Perhaps one of the most debated topics in medicine, the cholesterol controversy, could only be brought to rest through the development of new clinical research methods that were capable of taking advantage of the amazing achievements in basic and pharmacological science after the second World War. It was only after understanding the biochemistry and physiology of cholesterol synthesis, transport and clearance from the blood that medicine could take advantage of drugs and diets to reduce the risk of atherosclerotic diseases. This review points to the highlights of the history of low-density lipoprotein-cholesterol lowering, with the discovery of the low-density lipoprotein receptor and its physiology and not only the development of statins as the stellar moments but also the development of clinical trial methodology as an effective tool to provide scientifically convincing evidence.

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Citations

Nov 15, 2016·Expert Opinion on Drug Discovery·Yukinori Nagakura
Dec 16, 2016·Thrombosis and Haemostasis·Donato Santovito, Christian Weber
Jun 9, 2017·Thrombosis and Haemostasis·Christian WeberEmiel P C van der Vorst
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Nov 20, 2016·Cell Adhesion & Migration·Renske de JongOliver Soehnlein
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Oct 15, 2021·History and Philosophy of the Life Sciences·Carlo Martini, Mattia Andreoletti

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