The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib

Internal Medicine
Yoshinori MoriHirokazu Komatsu

Abstract

The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. The present case suggests that pazopanib may be a therapeutic option for extraosseous Ewing sarcoma.

References

May 12, 2010·Critical Reviews in Oncology/hematology·Fabio A B SchutzCora N Sternberg
Oct 19, 2011·International Journal of Surgical Pathology·Eugenia BancalariJuan C Tardío
Jul 22, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yutaka YamamotoHirotsugu Uemura
Oct 28, 2014·Acta Oncologica·Thierry Alcindor
Aug 13, 2015·Rare Tumors·Steven AttiaRobert G Maki
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie GasparOdile Oberlin
Sep 28, 2016·World Journal of Orthopedics·Bivas Biswas, Sameer Bakhshi

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BETA
cesarean section
X-ray
surgical resection

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