The suitability of DNA cytometry for the prediction of the histological diagnosis in women with abnormal cervical smears

British Journal of Obstetrics and Gynaecology
A M van LeeuwenM P Burger

Abstract

To analyse the suitability of DNA cytometry for predicting the histological diagnosis in women with cervical dyskaryosis. Survey with the use of diagnostic information to revise disease probability. Colposcopy clinic of a university hospital. One hundred and ten women with two mildly or moderately dyskaryotic cervical smears and 98 women with one severely dyskaryotic smear. DNA cytometric analysis using cytocentrifuge preparations of single cell suspensions from a cervical scrape. The main DNA cytometric parameter was N5C (i.e. the absolute number of cells with a DNA content of more than 5C on a given surface with a predefined cell density). The probability of finding CIN II or worse. On arbitrary grounds, a positive test should point to a probability of 85% or higher. In the patients with cervical neoplasia, the value of N5C increased significantly with an increasing CIN grade (P < 0.001). In the patients with one severely dyskaryotic smear and in those with two mildly or moderately dyskaryotic smears, the prior probability of finding CIN II or worse was 94% and 53%, respectively. Therefore, DNA cytometric analysis might be particularly useful in women with mild or moderate dyskaryosis; further analysis was restricted to this ...Continue Reading

References

Jul 11, 1992·BMJ : British Medical Journal·D J AndersonA Templeton
Mar 18, 1989·BMJ : British Medical Journal·S M IsmailR G Newcombe
Mar 1, 1989·Journal of Clinical Pathology·A J RobertsonJ G Simpson
Nov 1, 1989·Pathology, Research and Practice·J S PloemJ J Ploem-Zaaijer
Sep 1, 1989·American Journal of Clinical Pathology·M BibboG L Wied
Apr 1, 1989·Pathology·J Hayman
Oct 1, 1981·Gynecologic Oncology·Y S FuR M Richart
Jan 1, 1994·British Journal of Obstetrics and Gynaecology·D LuesleyJ Buxton
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·T M WagnerJ J Ploem-Zaaijer
Nov 1, 1993·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M.P.M. Burger, H. Hollema

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