The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia

Nature Communications
Nils OttoChristian Klämbt

Abstract

Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity.

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Citations

Dec 5, 2019·Metallomics : Integrated Biometal Science·Johana Vásquez-ProcopioFanis Missirlis
Dec 17, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·F Rob JacksonLauren B Crowe
Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
Nov 18, 2018·Glia·Kerem YildirimChristian Klämbt
Jul 15, 2020·International Journal of Molecular Sciences·Taejoon KimIm-Soon Lee
Jul 10, 2019·Communications Biology·Kristen M LeeMike Grotewiel
Jan 12, 2020·Communications Biology·Kristen M LeeMike Grotewiel
Mar 17, 2021·Annual Review of Neuroscience·Klaus-Armin Nave, Hauke B Werner

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Methods Mentioned

BETA
imaging technique
dissection

Software Mentioned

Excel
MatLab
FIMtrack
GRASP
Zeiss LSM
Spike2
SigmaPlot

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