The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes.

Scientific Reports
Ana PereiraCristina M Sena

Abstract

In this study we investigate pyridoxamine (PM) and/or sulforaphane (SFN) as therapeutic interventions to determine whether activators of NFE2-related factor 2 (Nrf2) can be used in addition with inhibitors of advanced glycation end products (AGE) formation to attenuate oxidative stress and improve endothelial dysfunction in type 2 diabetes. Goto-kakizaki (GK) rats, an animal model of non-obese type 2 diabetes, were treated with or without PM and/or SFN during 8 weeks and compared with age-matched Wistar rats. At the end of the treatment, nitric oxide (NO)-dependent and independent vasorelaxation in isolated aorta and mesenteric arteries were evaluated. Metabolic profile, NO bioavailability and vascular oxidative stress, AGE and Nrf2 levels were also assessed. Diabetic GK rats presented significantly lower levels of Nrf2 and concomitantly exhibited higher levels of oxidative stress and endothelial dysfunction. PM and SFN as monotherapy were capable of significantly improving endothelial dysfunction in aorta and mesenteric arteries decreasing vascular oxidative damage, AGE and HbA1c levels. Furthermore, SFN + PM proved more effective reducing systemic free fatty acids levels, normalizing endothelial function, NO bioavailability a...Continue Reading

References

Oct 28, 1999·Cardiovascular Research·F Cosentino, T F Lüscher
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J W Fahey, P Talalay
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Feb 19, 2002·Kidney International·Thorsten P DegenhardtJohn W Baynes
May 21, 2005·Cellular and Molecular Life Sciences : CMLS·P A Voziyan, B G Hudson
Oct 19, 2005·British Journal of Pharmacology·Hong DingChris Triggle
Dec 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mohammad Hossein Noyan-AshrafBernhard H J Juurlink
Jan 27, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna-Liisa LevonenSeppo Ylä-Herttuala
Oct 2, 2007·British Journal of Pharmacology·C M SenaR M Seiça
Jan 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Su-Yen Goh, Mark E Cooper
May 2, 2008·Annals of the New York Academy of Sciences·Vincent M MonnierJianye Zhang
Jun 24, 2008·The American Journal of Cardiology·Bradley J WillcoxBeatriz L Rodriguez
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Nov 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Gerasimos P SykiotisDirk Bohmann
Dec 7, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Carlos Enrique Guerrero-BeltránYolanda Irasema Chirino
Jan 22, 2011·British Journal of Pharmacology·Cristina M SenaRaquel M Seiça
May 24, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Mar 20, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cristina M SenaRaquel M Seiça
May 12, 2012·The International Journal of Biochemistry & Cell Biology·Sarah J ChappleGiovanni E Mann
Aug 29, 2012·Journal of Medicinal Food·Carolina Guerini de SouzaDiogo Onofre Souza
Sep 19, 2012·Atherosclerosis·Bernhard H J Juurlink
Jul 12, 2013·Cardiovascular Therapeutics·Filipa AlmeidaRaquel Seiça
Sep 3, 2013·Biochimica Et Biophysica Acta·Cristina M SenaRaquel Seiça
Feb 25, 2014·Redox Report : Communications in Free Radical Research·Sih Min Tan, Judy B de Haan
Mar 22, 2014·Trends in Biochemical Sciences·John D Hayes, Albena T Dinkova-Kostova
Feb 24, 2015·Current Topics in Medicinal Chemistry·Tharmarajan RamprasathGovindan Sadasivam Selvam
Oct 16, 2015·Free Radical Biology & Medicine·Giovanni E Mann

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Citations

Oct 20, 2018·Expert Opinion on Investigational Drugs·Juan Antonio MorenoJesus Egido
Jul 7, 2020·Journal of Cellular and Molecular Medicine·Junduo WuHao Wu
Dec 20, 2018·Frontiers in Physiology·Cristina M SenaGeorge Perry
May 16, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brayden D HalvorsonJefferson C Frisbee
Apr 30, 2019·Frontiers in Pharmacology·Rafael M da CostaRita C Tostes
Nov 24, 2019·Trends in Endocrinology and Metabolism : TEM·Rasmus Kold-Christensen, Mogens Johannsen
Oct 26, 2020·Free Radical Biology & Medicine·Adriana LeandroCristina M Sena
Nov 5, 2020·Antioxidants·Gemma AragonèsEloy Bejarano
Jul 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mathias D G Van den EyndeCasper G Schalkwijk
Jul 25, 2021·International Journal of Environmental Research and Public Health·Juan SalazarValmore Bermúdez

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Methods Mentioned

BETA
confocal microscopy
glycation
Transgenic
urine collected
electrophoresis
protein assay

Software Mentioned

GraphPad Prism
LabChart

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