PMID: 6414075May 1, 1983Paper

The sulphate content of dermal and urinary glycosaminoglycans in psoriatics with increased excretion and increased dermal content of glycosaminoglycans

Scandinavian Journal of Clinical and Laboratory Investigation
J H Poulsen, M K Cramers

Abstract

The investigation included 17 psoriatics and 19 healthy controls. The content of sulphate per disaccharide unit (sulphate/uronic acid ratio) was measured in the sulphated glycosaminoglycans (GAGs) isolated from urine and dermal biopsies of the gluteal region. Biopsies were taken from both involved and uninvolved skin of the psoriatics. Perfectly normal sulphate/uronic acid ratios were found in the involved and uninvolved skin as well as in the urine of the psoriatics. A close and positive correlation between the sulphate/uronic acid ratio of the sulphated GAGs in the affected and unaffected skin of the psoriatics was discovered. The results are discussed in relation to earlier findings on the same specimens which shows that the concentration of sulphated GAGs in the psoriatic lesions is increased (28%) as is the urinary excretion of sulphated GAG in the same patients (62%).

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Clinical and Laboratory Investigation
J H Poulsen, M K Cramers
Clinica Chimica Acta; International Journal of Clinical Chemistry
J H Poulsen, M K Cramers
Acta Obstetricia Et Gynecologica Scandinavica
E B OlsenT Ammitzbøll
© 2021 Meta ULC. All rights reserved