The SUMO pathway promotes basic helix-loop-helix proneural factor activity via a direct effect on the Zn finger protein senseless.

Molecular and Cellular Biology
Lynn M PowellA P Jarman

Abstract

During development, proneural transcription factors of the basic helix-loop-helix (bHLH) family are required to commit cells to a neural fate. In Drosophila neurogenesis, a key mechanism promoting sense organ precursor (SOP) fate is the synergy between proneural factors and their coactivator Senseless in transcriptional activation of target genes. Here we present evidence that posttranslational modification by SUMO enhances this synergy via an effect on Senseless protein. We show that Senseless is a direct target for SUMO modification and that mutagenesis of a predicted SUMOylation motif in Senseless reduces Senseless/proneural synergy both in vivo and in cell culture. We propose that SUMOylation of Senseless via lysine 509 promotes its synergy with proneural proteins during transcriptional activation and hence regulates an important step in neurogenesis leading to the formation and maturation of the SOPs.

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Citations

Jun 20, 2013·Genesis : the Journal of Genetics and Development·Umair KhanGirish S Ratnaparkhi
Oct 24, 2014·Molecular Neurobiology·Tiantian Cai, Andrew K Groves
Jan 1, 2012·Biomolecules·Matthew SmithAlbert J Courey
Aug 24, 2018·International Journal of Molecular Sciences·Pin Yao WangAngela Chen
Mar 10, 2016·Molecular and Cellular Biology·Daniel AndradeMichael E Engel

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