PMID: 8964597Jan 1, 1996Paper

The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes

Immunology Letters
T M ZollnerR Kaufmann

Abstract

Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell receptor variable gene usage has been demonstrated within these lesions. Therefore, the question arises whether superantigen induce a skin-seeking phenotype within peripheral T cells. In this study, we investigated the in vitro influence of the V beta 2-selective superantigen exfoliative toxin from Staphylococcus aureus on the expression of the cutaneous lymphocyte-associated antigen on peripheral T lymphocytes of healthy donors. We demonstrate that exfoliative toxin dramatically upregulates cutaneous lymphocyte-associated antigen expression on T cell receptor V beta 2+ lymphocytes. Up to 69% of V beta 2+ lymphocytes expressed cutaneous lymphocyte-associated antigen after 5 days of in vitro culture. Additionally, exfoliative toxin also increased cutaneous lymphocyte-associated antigen expression in CD3+ T cell receptor V beta 2- lymphocytes indicating a different effect as caused by the superantigen-T cell receptor V beta 2 interaction. Our findings suggest influence of ba...Continue Reading

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M D HowellS W Brostoff
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiJ Kappler

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Citations

Oct 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·H Müller-AloufJ E Alouf
Apr 18, 2000·Infection and Immunity·L R PlanoC M Collins
Mar 6, 2002·The Journal of Clinical Investigation·Thomas M ZollnerWolf-Henning Boehncke
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael R Ardern-JonesGraham S Ogg
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T M ZollnerR Kaufmann
Dec 2, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Ogg

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