The superior vena cava syndrome: clinical characteristics and evolving etiology

Medicine
Todd W RiceRichard W Light

Abstract

Malignancy is the most common cause of the superior vena cava (SVC) syndrome. With the increasing use of intravascular devices, the incidence of the SVC syndrome arising from benign etiologies is increasing. We reviewed the etiology and outcome of 78 patients with SVC syndrome over 5 years. Malignancy was the etiology in 60% of the cases, and bronchogenic carcinoma was the most common malignancy. Small cell and non-small cell lung cancer accounted for 17 (22%) and 19 (24%) cases, respectively, but a higher percentage of patients with small-cell lung cancer developed the syndrome (6% vs 1%). Lymphoma and germ cell tumors were other significant malignant causes (8% and 3% of cases, respectively). An intravascular device was the most common etiology in benign cases (22 of 31 cases; 71%), with fibrosing mediastinitis the second most common benign etiology (6 cases). The most frequent signs and symptoms were face or neck swelling (82%), upper extremity swelling (68%), dyspnea (66%), cough (50%), and dilated chest vein collaterals (38%). Dyspnea at rest, cough, and chest pain were more frequent in the patients with malignancy. Procedures performed for diagnostic or treatment purposes did not increase morbidity or mortality.

References

May 1, 1990·The American Review of Respiratory Disease·A YellinY Lieberman
Sep 1, 1985·Cancer Treatment Reviews·J P Sculier, R Feld
May 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LokichC Moore
Sep 1, 1985·The Annals of Thoracic Surgery·A G LittleD B Skinner
Aug 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R Ahmann
Jun 1, 1981·The American Journal of Medicine·D E SchraufnagelJ A Pare
Mar 6, 1981·JAMA : the Journal of the American Medical Association·D S ShimmL C Rigsby
Feb 8, 1993·Archives of Internal Medicine·T UrbanJ Sauvaget
Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Richie Chiu-Lung ChanW I Kocha
Feb 2, 1999·Cleveland Clinic Journal of Medicine·M Markman
Nov 5, 1999·Radiologic Clinics of North America·M J Hogan
Jun 10, 2000·Chest·K J NikulaC Hobbs
Apr 26, 2001·American Heart Journal·C SticherlingB P Knight
Aug 25, 2001·Seminars in Respiratory Infections·A M DavisJ E Loyd
Aug 25, 2001·Seminars in Respiratory Infections·S Mocherla, L J Wheat
Aug 2, 2003·Journal of Vascular Surgery·Manju KalraPeter C Pairolero
Aug 5, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R García MónacoB C Vassallo
Jan 1, 1954·The American Journal of the Medical Sciences·M M SCHECHTER
Jan 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A UrruticoecheaJ R Germà
Mar 20, 2004·Respiration; International Review of Thoracic Diseases·Laurent GreillierJean-Pierre Kleisbauer
Jul 14, 2004·Clinical Nuclear Medicine·Ba D Nguyen, Michael C Roarke
Aug 7, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Simon BaysAnthony Morgan

Citations

Mar 12, 2011·Cardiovascular and Interventional Radiology·Ryan Jean-BaptisteJoseph J Gemmete
Feb 26, 2013·Journal of General Internal Medicine·Kieran L Quinn, Christopher A Smith
Jan 29, 2011·Current Treatment Options in Cardiovascular Medicine·Ronan Margey, Robert M Schainfeld
Aug 16, 2008·Neurocritical Care·Alejandro A Rabinstein, Eelco F M Wijdicks
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Timothy James WigmoreAndrew Lawson
May 4, 2007·The New England Journal of Medicine·Lynn D WilsonJoachim Yahalom
Jan 12, 2013·Interactive Cardiovascular and Thoracic Surgery·Richie Chiu-Lung ChanStephen Wing-Keung Cheng
Jan 10, 2012·QJM : Monthly Journal of the Association of Physicians·A SchattnerM Adi
Jun 21, 2008·BMJ : British Medical Journal·Anthony F WatkinsonClementine Fraser
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Donald R Duerksen
Jun 26, 2008·Cases Journal·Khaled M MusallamAli I Shamseddine
Oct 13, 2011·Medicine and Science in Sports and Exercise·Shaoyan ZhangTina L Hurst
Mar 1, 2012·Journal of Cardiovascular Medicine·Prabhat HebbarHakan Paydak
Jan 1, 2012·Journal of Community Hospital Internal Medicine Perspectives·Agegnehu T GebreyesSapna P Kuehl
Nov 23, 2013·Medicine and Science in Sports and Exercise·Alex V RowlandsJoss Langford
Jul 6, 2014·Journal of Cancer Research and Clinical Oncology·Karin HohlochFrank Griesinger
May 15, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jiri BartekTiit Mathiesen
Apr 3, 2012·The American Journal of Emergency Medicine·Jamie S JohnsonBrett F Bechtel
Sep 14, 2011·The Journal of Emergency Medicine·Michelle M CrispoGeorge L Higgins
Aug 12, 2009·Current Problems in Cardiology·Suhail AllaqabandTanvir Bajwa
Oct 10, 2007·Clinical Lung Cancer·Ahmet UrsavaşR Oktay Gozu
Apr 5, 2013·Seminars in Dialysis·Unnikrishnan PillaiPaul Kissner
Aug 11, 2011·The Breast Journal·Morgan Roth Goldberg, Phillip H Kuo
Oct 29, 2015·Clinical Case Reports·Mohammed S Al-NatourDaniel Gaudin
Sep 23, 2008·The American Journal of Cardiology·Paul D SteinAbdo Y Yaekoub
Feb 23, 2008·The Annals of Thoracic Surgery·Brian E KogonWendy M Book
Jul 8, 2015·International Journal of Surgery Case Reports·Julian HamzikPeter Kubisz
Mar 5, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Gerard J O'SullivanAnn Michelle Browne
Mar 27, 2015·Case Reports in Oncological Medicine·Joana Espírito SantoRui Marques Dos Santos
Mar 24, 2010·AJR. American Journal of Roentgenology·Sheila ShethElliot K Fishman
Apr 9, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shane M MeskoOmid Hamid
Jul 7, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chun-Hsiang YuHang-Yu Chang
Aug 12, 2016·Journal of Oncology Practice·Kipp WeiskopfMelinda L Telli
Jun 28, 2016·Semergen·J Fuentes Cruzado, M A E Renilla Sánchez
Apr 4, 2014·The Annals of Thoracic Surgery·Huadong LiTucheng Sun
Jun 26, 2017·Annals of Vascular Surgery·Yusuf ChauhanEric K Peden
Apr 8, 2017·Mayo Clinic Proceedings·Thorvardur R HalfdanarsonBo E Madsen
Jun 28, 2017·Cardiology·Sundeep ShenoySasikanth Adigopula
Oct 23, 2012·Asian Cardiovascular & Thoracic Annals·Stephen E Thwaites, Peter A Robless
Mar 30, 2018·The Journal of Vascular Access·Chen L YaoZheng Y Yu
Dec 24, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Susanne AntonJan Peter Goltz
Jun 6, 2015·The Journal of Vascular Access·Julia TonakJan Peter Goltz
Dec 26, 2017·Hospital Pharmacy·Michael J ScaleseSara Lott
Jun 7, 2018·The New England Journal of Medicine·Ersilia M DeFilippisJoseph Loscalzo
Mar 25, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Bruce Gray
Feb 14, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mert DumantepeAzmi Ozler
Sep 14, 2011·The Mount Sinai Journal of Medicine, New York·Sara Axelrod, Mark Davis-Lorton
Apr 17, 2014·Circulation. Cardiovascular Interventions·John O'Dea, Robert M Schainfeld
Aug 8, 2012·Circulation·Rolf P Engelberger, Nils Kucher
Apr 26, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Todd W RiceRichard W Light
Mar 24, 2007·Nature Clinical Practice. Cardiovascular Medicine·Cheng E CheeAbhiram Prasad
Sep 27, 2007·Respiration; International Review of Thoracic Diseases·D PlekkerA H Diacon
Oct 10, 2007·Hemodialysis International·Hadim AkogluCetin Turgan
Nov 2, 2018·Internal and Emergency Medicine·Glenda Maria Delgado RamosShadwan Alsafwah
Apr 24, 2010·Congenital Heart Disease·Matthew E FergusonDonald J Hagler
Feb 18, 2017·Breathe
Apr 16, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Brian DeeAlison Gulbis
Aug 1, 2006·Photomedicine and Laser Surgery
May 16, 2012·Critical Care Medicine·Michael T McCurdy, Carl B Shanholtz
Apr 16, 2020·Ear, Nose, & Throat Journal·Mohamed BassiouniSteffen Dommerich
Apr 26, 2020·Journal of Clinical Ultrasound : JCU·Pablo BlancoIvana Leonardi
Aug 14, 2012·British Journal of Haematology·Campbell TaitBritish Committee for Standards in Haematology
Apr 3, 2018·Annals of the Royal College of Surgeons of England·T Lloyd JonesS M Hayes
Mar 19, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yoel Siegel, Russ Kuker
Oct 17, 2019·Jornal Vascular Brasileiro·Walter Kegham KarakhanianSergio Quilici Belczak
Oct 31, 2018·Texas Heart Institute Journal·Jared B HookerMazen S Abu-Fadel
Sep 27, 2018·Journal of Thrombosis and Thrombolysis·Roy RatzonAvi Leader
Aug 16, 2019·Indian Journal of Palliative Care·Ekta DhamijaSanjay Thulkar
Jun 18, 2020·SAGE Open Medical Case Reports·Rochelle Tonkin, Christopher Sladden
Sep 11, 2020·Case Reports in Anesthesiology·Matthew B EllisonPavithra R Ellison
Oct 19, 2017·Case Reports in Oncological Medicine·Vanesa Varela PoseRafael Lopez Lopez
Aug 25, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sarah MorinEmmanuel Canet
Dec 12, 2019·BMJ Case Reports·Amr ElmoheenKhalid Bashir
Jul 28, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Deepak RamnaniRajeev Upreti
Jan 1, 2011·Wiener Klinische Wochenschrift. Education·Peter Schellongowski
Jun 3, 2017·Korean journal of family medicine·Jin Ho JangHye Ju Yeo
Dec 18, 2019·Skeletal Radiology·Daniel Walker, Zaid Jibri
Nov 19, 2019·Journal of Computer Assisted Tomography·Shlomit TamirAvi Leader
Apr 3, 2020·Surgical and Radiologic Anatomy : SRA·Dmitri Mihaylovich Gordionok, Sergey Dmitrievich Denisov
Oct 29, 2020·VASA. Zeitschrift für Gefässkrankheiten·Houman JalaieMohammad Esmaeil Barbati
Dec 29, 2020·JACC. Cardiovascular Interventions·Abdul Hussain AziziRiyaz Bashir
Feb 7, 2021·Journal De Médecine Vasculaire·S MleyhiR Denguir

Related Concepts

Non-Small Cell Lung Carcinoma
Chest Pain
Differential Diagnosis
Dyspnea
Anasarca
Malignant Neoplasm of Lung
Lymphoma
Cancer, Embryonal and Mixed
Retrospective Studies
Superior Vena Cava Thrombosis

Related Feeds

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.

Related Papers

The New England Journal of Medicine
Lynn D WilsonJoachim Yahalom
Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Islam BoladDavid Martin
© 2021 Meta ULC. All rights reserved