The suppression of the long-latency stretch reflex in the human tibialis anterior muscle by transcranial magnetic stimulation

Experimental Brain Research
Johan van DoornikJ Nielsen

Abstract

The purpose of this study was to investigate the transcortical nature of the long-latency stretch reflex (M3) in the human tibialis anterior muscle. This was achieved by applying a single pulse of subthreshold (90% motor threshold) transcortical magnetic stimulation (subTMS) at the site of the motor cortex. Such a stimulus is able to activate intracortical inhibitory circuits and thereby depress motor cortical output. We hypothesized that it would also suppress a transcortical reflex loop. The stretch reflex was elicited using a pedal attached to an electric motor. SubTMS was applied at several intervals prior to M3. Recordings were repeated 20-40 times. The reflex components were quantified using 20-ms windows in the averaged rectified electromyogram (EMG). SubTMS evoked significantly larger depression of M3 than of the background EMG in the same time frame when applied 55-85 ms prior to M3 ( P<0.05, n=10). Furthermore, the effect on M3 was significantly larger than the effect on the spinal M2 ( P<0.01, n=7). Our results provide evidence that the long-latency stretch reflex in the tibialis anterior muscle is at least partly transcortical.

Citations

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