The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease

Microbiology and Immunology
Tadahiko ShibaYasuhiro Koga

Abstract

Bacteroides, a predominant commensal bacteria in the gut, are thought to be responsible for the development of inflammatory bowel disease (IBD). In the present study, we examined whether or not bifidobacteria suppress B. vulgatus, a representative pathogenic Bacteroides species, in both the coculture system and the gnotobiotic murine model. As a result, Bifidobacterium infantis 1222 highly inhibited the growth of B. vulgatus in the coculture and also significantly suppressed the systemic antibody response raised by B. vulgatus colonizing the gut in gnotobiotic mice. Colonization of the mice by B. vulgatus increased the number of Peyer's patch (PP) cells bearing PNA (peanut agglutinin)+/anti-kappa+ phenotype, which represents plasma cell-like B cells. Moreover, treatment of those B. vulgatus-implanted mice with B. infantis 1222 abrogated such increase in the number of PNA+/anti-kappa+ cells. These results thus suggested that B. infantis 1222 protected the gut epithelial layer including the PP from being invaded by Bacteroides, thereby suppressing the systemic antibody response raised by Bacteroides.

References

Feb 28, 2006·Journal of Gastroenterology·Toshifumi Hibi, Haruhiko Ogata
Nov 6, 2004·Current Gastroenterology Reports·Gil Y Melmed, Maria T Abreu
Feb 11, 2005·Current Opinion in Gastroenterology·Gerhard Rogler
Feb 11, 2005·Current Opinion in Gastroenterology·Fang Yan, D Brent Polk
Mar 1, 2005·Inflammatory Bowel Diseases·Desiree CamuescoJulio Galvez
Jul 10, 2012·Applied and Environmental Microbiology·E SánchezY Sanz
Mar 16, 2007·Digestive Diseases and Sciences·Rasha KamilGordon S Howarth
Sep 28, 2007·International Journal of Medical Microbiology : IJMM·Hiromasa TakaishiToshifumi Hibi
Jan 16, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Namju KimH Kiyono
May 27, 2005·Journal of Applied Microbiology·S C LeahyD van Sinderen
Dec 25, 2010·European Journal of Immunology·Amlan BiswasKoichi S Kobayashi
Aug 30, 2005·Advances in Pediatrics·Chien-Chang Chen, W Allan Walker
Aug 9, 2005·Gastroenterology Clinics of North America·Kevin P RiouxR N Fedorak
Jul 11, 2012·Biotechnology Advances·Rudolf Deutschmann, Robert F H Dekker
Dec 30, 2014·Frontiers in Microbiology·Austin G Davis-RichardsonEric W Triplett
Oct 5, 2017·International Journal of Molecular Sciences·Daniel A MedinaDaniel Garrido
Feb 19, 2008·British Journal of Clinical Pharmacology·Dimitrios Damaskos, George Kolios
Jul 14, 2010·Bioscience, Biotechnology, and Biochemistry·Hiroki IshikawaTetsuya Matsumoto
Jun 24, 2004·Clinical Science·Yashwant R Mahida, Vivien E Rolfe
Jul 31, 2020·Gut Microbes·Ana Maldonado-ContrerasAndrew Hoffman
Jul 6, 2019·Frontiers in Microbiology·Elisabeth LavilleGabrielle Potocki-Veronese
Jul 12, 2020·European Journal of Nutrition·Anthony K AkobengSouhaila Al Khodor
Oct 27, 2020·Expert Review of Clinical Immunology·Katherine L OlshanAlessio Fasano

Citations

Jan 1, 1992·Microbiology and Immunology·Y Benno, T Mitsuoka
May 1, 1989·The Journal of Applied Bacteriology·R Fuller
Mar 1, 1989·FEMS Microbiology Letters·J G Ruseler-van EmbdenL M van Lieshout
Sep 1, 1983·Scandinavian Journal of Gastroenterology·M TvedeS N Rasmussen
Jan 1, 1995·The British Journal of Surgery·M A ChapmanN S Williams
Aug 1, 1997·Infection and Immunity·R D WagnerE Balish
Apr 20, 1999·The Journal of Experimental Medicine·T DohiJ R McGhee
Apr 30, 1999·Gastroenterology·K L MadsenR N Fedorak

Related Concepts

Microorganism
Structure of Aggregated Lymphoid Follicle of Small Intestine
Bifidobacterium
Gnotobiotics
Bacteroides species
Mice, Inbred BALB C
Pathogenic Organism
Coculture Techniques
Murine
IgG2B

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.