The suppressive effect of the three-herb extract mixture on vascular and liver inflammation in atherogenic diet with high fructose-fed mice

Pharmaceutical Biology
Hae Seong SongSe Chan Kang

Abstract

Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L. var. rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity. The synergistic effect of three-herb mixture of C. wilfordii, A. lappa and D. opposita was determined on aortic and liver inflammatory responses. CWE, ALE and DOE were prepared from the root of C. wilfordii, A. lappa and D. opposite by 70% ethanol extraction, respectively. CADE was prepared using a powder mixture of 2 CWE:1 ALE:1 DOE. C57BL/6 mice were fed an atherogenic diet combined with 10% fructose (ATHFR) in the presence of 200 mg/kg/day CWE, ALE, DOE or CADE for 8 weeks (each group, n = 6). Biochemical profiles, protein expression of vascular cell adhesion molecule-1 (VCAM-1) on the aorta and liver were determined. CADE could significantly suppress the protein expression of VCAM-1 in both the aorta and liver (80% reduction) compared to ATHFR-fed mice. Impairment of liver function was significantly ameliorated by CADE supplement, as determined by GOT (60% reduction) and GPT (51% reduction) levels. CADE should be considered when developing medications to suppress the vascular and liver inflammat...Continue Reading

References

Apr 1, 1995·Journal of Pharmacological and Toxicological Methods·S Dai, J H McNeill
May 4, 1999·The American Journal of Medicine·L PetruzzelliH D Humes
Aug 7, 2001·Current Atherosclerosis Reports·T A Jacobson
Nov 7, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M Williamson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 1, 2003·Journal of Clinical Epidemiology·William S Weintraub
Feb 7, 2003·Current Medicinal Chemistry·Benjamin Gilbert, Lucio Ferreira Alves
Sep 16, 2004·Journal of Agricultural and Food Chemistry·María Jesús PeriagoGaspar Ros
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jan 9, 2007·Lancet·Raj S Padwal, Sumit R Majumdar
Jan 17, 2007·Metabolism: Clinical and Experimental·Serena TonstadIngebjørg Seljeflot
Sep 19, 2007·Journal of Internal Medicine·A W Ferrante
Oct 9, 2007·The American Journal of Clinical Nutrition·Isabelle AeberliKaspar Berneis
Jun 21, 2011·International Journal of Molecular Sciences·Alba Fernández-SánchezJosé A Morales-González
Jun 23, 2011·JAMA : the Journal of the American Medical Association·David PreissKausik K Ray
Jul 12, 2012·Experimental Parasitology·Adriana Matias da SilvaJosé Roberto Machado-Silva
Aug 8, 2012·BMC Complementary and Alternative Medicine·Yun Jung LeeHo Sub Lee
Jul 24, 2013·European Journal of Cell Biology·Aus Tariq AliMichael S Pepper
Feb 28, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Yu KataokaStephen J Nicholls
Sep 26, 2015·Journal of Digestive Diseases·Münevver DemirHans-Michael Steffen
Jan 10, 2016·BMC Complementary and Alternative Medicine·Zhi WangChunbo Wang
May 31, 2016·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros
Jun 18, 2016·Journal of Lipid Research·Marleen SchonewilleAlbert K Groen

❮ Previous
Next ❯

Datasets Mentioned

BETA
NMR256

Methods Mentioned

BETA
PCR
fluorescence microscopy

Software Mentioned

Image J
Olympus DP controller

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.