The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair

The Journal of Investigative Dermatology
Andreas LinkeStefan Frank

Abstract

Recently, the suppressor of cytokine signaling (SOCS)-3 has been shown to be expressed in disturbed wound margin epithelia during diabetes-impaired wound healing in mice. To functionally connect a potential contribution of SOCS-3 expression to the control of wound keratinocyte behavior in skin repair, we created a transgenic mouse (tsgn-K5/SOCS3) overexpressing SOCS-3 in keratinocytes using the bovine keratin 5 promoter. Tsgn-K5/SOCS3 mice showed a constitutive expression of SOCS-3 in the basal layer of skin epidermis. Keratinocytes of tsgn-K5/SOCS3 mice showed full inhibition of signal transducer and activator of transcription (STAT)-3 phosphorylation. Tsgn-K5/SOCS3 keratinocytes also showed a strong inhibition of migratory and proliferative potential in vitro. In addition, tsgn-K5/SOCS3 keratinocytes co-expressed the differentiation marker loricrin in the basal layer of nonwounded skin in vivo. Upon wounding, wound tissues of tsgn-K5/SOCS3 mice showed an impairment of wound closure characterized by strongly atrophied wound margin epithelia. Atrophied epithelia of tsgn-K5/SOCS3 mice exhibited a marked reduction in proliferating cells and reduced total keratinocyte numbers. In summary, this study suggests that the presence of S...Continue Reading

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Citations

May 18, 2012·Cytokine & Growth Factor Reviews·Yi LiC Janneke van der Woude
Mar 27, 2013·The Journal of Investigative Dermatology·Tomonori TakekoshiSam T Hwang
Apr 23, 2011·Archives of Oral Biology·João Antonio Chaves de SouzaCarlos Rossa
Mar 18, 2015·Molecular and Cellular Biology·Jonathan A CooperShawn S C Li
Jul 12, 2011·Physiological Reviews·Danish Sayed, Maha Abdellatif
Dec 20, 2017·Molecular Medicine Reports·Xianren WangRongzhan Fu
Nov 7, 2019·Biochemistry. Biokhimii︠a︡·P A AbramichevaO V Smirnova
Feb 16, 2016·Regenerative Medicine·Yi FengWen G Jiang

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