The surface and transport properties of meconium and reconstituted meconium solutions

Pediatric Research
B K RubinD Easa

Abstract

Passage of meconium in utero and subsequent pulmonary aspiration of meconium admixed with amniotic fluid is a major cause of neonatal respiratory distress. Airway clearance is the first defense of the lung, and clearance is dependent on the bulk physical (rheologic) as well as the surface properties of airway material. We therefore evaluated the surface adhesive properties and the transport properties of freshly passed meconium and of two dilutions of reconstituted, blended, meconium as used to mimic the effect of meconium passage into the amniotic fluid in animal models of meconium aspiration syndrome. Reconstituted and fresh meconium had similar physical and transport properties, including an extremely high interfacial (adhesion) tension and very poor transportability by either airflow or cilia. The similarities between the freshly passed and reconstituted meconium suggest that the latter is an adequate substitute for use in animal models of meconium aspiration syndrome. The high adhesiveness of meconium suggests a potential role for surfactant administration as an adhesive to improve airway clearance after meconium aspiration.

References

May 1, 1992·Pediatric Pulmonology·M A WallenbrockP L Toubas
Jun 1, 1992·Pediatric Research·M S ParankaB B Stancombe
Feb 1, 1991·American Journal of Obstetrics and Gynecology·D MosesG Enhorning
Aug 1, 1990·Journal of Applied Physiology·B K RubinM King
Apr 1, 1990·Respiration Physiology·S SchürchF Green
Nov 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·H C RyleyD M Bradley
Apr 1, 1982·The Journal of Physiology·B A Hills
Oct 1, 1993·Pediatric Clinics of North America·T E Wiswell, R C Bent

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Citations

Jun 12, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Babatunde I. OnasanyaBillie L. Short
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mamta FuloriaBruce K Rubin
Apr 15, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Bradley P Fuhrman
Jan 7, 2005·Pediatric Research·Paal H H LindenskovOla D Saugstad
Jan 6, 2006·Drugs·Peter A Dargaville, John F Mills
Jan 8, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F M AkgürE Ozer
Apr 21, 2012·International Journal of Pediatrics·Peter A Dargaville
May 23, 2007·European Journal of Pediatrics·Jasper V Been, Luc J I Zimmermann
Oct 20, 2009·Early Human Development·Sarah H Poggi, Alessandro Ghidini
May 20, 2015·Intractable & Rare Diseases Research·Keiichi UchidaMasato Kusunoki
Apr 25, 2008·Biochimica Et Biophysica Acta·Yi Y ZuoFred Possmayer
Feb 2, 2011·Biophysical Journal·Elena Lopez-RodriguezJesus Perez-Gil
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·A Asad, R Bhat
Mar 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jana KopincovaDaniela Mokra

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