The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor

Molecular and Biochemical Parasitology
Tsui-Ling HsuAlvaro Díaz

Abstract

The larvae of the cestodes belonging to the genus Echinococcus dwell primarily in mammalian liver. They are protected by the laminated layer (LL), an acellular mucin-based structure. The glycans decorating these mucins constitute the overwhelming majority of molecules exposed by these larvae to their hosts. However, their decoding by host innate immunity has not been studied. Out of 36 mammalian innate receptors with carbohydrate-binding domains, expressed as Fc fusions, only the mouse Kupffer cell receptor (KCR; CLEC4F) bound significantly to the Echinococcus granulosus LL mucins. The receptor also bound the Echinococcus multilocularis LL. Out of several synthetic glycans representing Echinococcus LL structures, the KCR bound strongly in particular to those ending in Galα1-4Galβ1-3 or Galα1-4Galβ1-4GlcNAc, both characteristic LL carbohydrate motifs. LL carbohydrates may be optimized to interact with the KCR, expressed only in liver macrophages, cells known to contribute to the tolerogenic antigen presentation that is characteristic of this organ.

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Citations

Jun 26, 2014·Veterinary Parasitology·Silke RiesleRodolfo Paredes
Oct 2, 2015·Parasite Immunology·A DíazA M Ferreira
Oct 13, 2015·Parasite Immunology·A N PeónL I Terrazas
Mar 31, 2015·Experimental Parasitology·Álvaro DíazCecilia Casaravilla
Oct 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jung-Tsu ChenChi-Huey Wong
Sep 7, 2020·International Journal of Biological Macromolecules·Sebastián MilesGustavo Mourglia-Ettlin

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