The surface character of separated prostatic cells and cultured fibroblasts of prostatic tissue as determined by concanavalin-A hemadsorption

The Prostate
K OishiF H Schroeder

Abstract

Con-A-coated human type O red blood cells (indicator RBC) were used for ConA reactivity assay of separated epithelial cells and cultured fibroblasts of human prostatic tissue. The epithelial cells of carcinoma showed higher reactivity than those of normal tissue or hyperplastic tissue. Although both cultured fibroblasts of PC and BPH are considered to be non-malignant, it is clearly demonstrated that the PC fibroblasts have a malignant surface character in terms of ConA reactivity, whereas the BPH fibroblasts have a quite low ConA reactivity. ConA-mediated HAD appeared to be a useful tool to distinguish malignant epithelial cells of human prostate from non-malignant ones. It still remains unknown whether the alteration of PC fibroblasts is the cause or the result of carcinogenic transformation of prostatic tissue.

References

Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·B A Voyles, C M McGrath
Jul 1, 1979·The Journal of Endocrinology·I Lasnitzki, T Mizuno
Jan 1, 1975·Advances in Experimental Medicine and Biology·I J Goldstein
Jan 1, 1972·The Journal of General Virology·J Calafat, P C Hageman
Jan 1, 1970·Advances in Cancer Research·I Macpherson
Jan 1, 1974·International Review of Cytology·G L Nicolson

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Citations

Nov 1, 1989·The Histochemical Journal·C HaukeF Sinowatz
Dec 21, 2002·Differentiation; Research in Biological Diversity·Gerald R CunhaY Z Wang
Apr 1, 1997·British Journal of Urology·S W HaywardG R Cunha
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Gerald R CunhaWilliam A Ricke
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Gerald R CunhaTakeshi Kurita
Apr 30, 1996·Annals of the New York Academy of Sciences·S W HaywardR Dahiya

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