PMID: 2503030Aug 22, 1989Paper

The surface properties of apolipoproteins A-I and A-II at the lipid/water interface

Biochimica Et Biophysica Acta
J A IbdahMichael C Phillips

Abstract

The monolayer system was employed to investigate the relative affinities of apolipoproteins A-I and A-II for the lipid/water interface. The adsorption of reductively 14C-methylated apolipoproteins to phospholipid monolayers spread at the air/water interface was determined by monitoring the surface pressure of the mixed monolayer and the surface concentration of the apoprotein. ApoA-II has a higher affinity than apoA-I for lipid monolayers; for a given initial surface pressure, apoA-II adsorbs more than apoA-I to monolayers of egg phosphatidylcholine (PC), distearoyl-PC and human high-density lipoprotein (HDL3) surface lipids. Comparison of the molecular packing of apolipoproteins A-I and A-II suggests that apoA-II adopts a more condensed conformation at the lipid/water interface compared to apoA-I. The ability of apoA-II to displace apoA-I from egg PC and HDL3 surface lipid monolayers was studied by following the adsorption and desorption of the reductively 14C-methylated apolipoproteins. At saturating subphase concentrations of the apoproteins (3.10(-5) g/100 ml), two molecules of apoA-II absorbed for each molecule of apoA-I displaced. This displacement was accompanied by an increase in surface pressure. An identical stoichiom...Continue Reading

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Citations

Nov 11, 1996·Biochimica Et Biophysica Acta·L CalabresiG Franceschini
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angelo M Scanu, Celina Edelstein
Apr 23, 2011·Journal of Molecular Biology·Lionel ChièzeVéronique Vié
Feb 22, 2013·Biochemistry·David NguyenMichael C Phillips
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Jun 2, 2009·Chemistry & Biology·Sergio OddiMauro Maccarrone
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Jul 21, 2016·Journal of Biological Physics·Ziad Khattari
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Mar 27, 2013·Journal of Lipid Research·Matthew A Mitsche, Donald M Small
Oct 4, 2013·Journal of Lipid Research·Eric T Alexander, Michael C Phillips
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Mar 1, 2018·The Journal of Physical Chemistry. B·Susanne DoganMetin Tolan

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