The survival benefit of resection in patients with advanced stomach cancer: the Norwegian multicenter experience. Norwegian Stomach Cancer Trial.

World Journal of Surgery
T HaugstvedtO Söreide

Abstract

Five hundred three of 1,165 patients with stomach cancer included in a national multicenter study received noncurative treatment. This study elucidates whether a palliative resection offered any survival advantage compared to nonresectional treatment. One hundred eighty-two (36%) of 503 patients had gastric resection (including total gastrectomy in 64 patients), 70 (14%) had a bypass procedure, and an exploratory laparotomy was carried out in 156 (31%). Seventy-eight patients (16%) were not subjected to surgery. Resection carried the same postoperative mortality rate as a nonresectional procedure (13% versus 12%). Univariate survival analysis demonstrated that median survival and 1- and 2-year survival rates were significantly higher in resected patients; however, as basic patient characteristics (age, stage, etc.) differed between the 2 main treatment groups, survival and factors affecting survival were analyzed using the Cox proportional hazards model. Given similar age and preoperative weight loss, resection doubled median survival both for stage III disease (9 versus 4.5 mo) and for stage IV disease (6 versus 3 mo) compared to nonresection or no operation. In conclusion, resection seems justified in patients with advanced s...Continue Reading

References

Nov 1, 1979·World Journal of Surgery·W H ReMine
Dec 1, 1978·Annals of Surgery·T W BuchholtzR A Malt
Jul 1, 1988·The British Journal of Surgery·B ValenO Søreide
Jan 1, 1988·The British Journal of Surgery·D KorenagaK Sugimachi
Feb 1, 1986·American Journal of Surgery·I SaarioM Lempinen
Nov 1, 1984·The British Journal of Surgery·M R KeighleyH Thompson

❮ Previous
Next ❯

Citations

Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·H J MeyerH Wilke
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·John WhitingMitsuru Sasako
Jul 14, 2009·International Journal of Clinical Oncology·Yuji YamamotoShinichi Hasegawa
May 14, 2005·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Sep 3, 1999·Journal of the American College of Surgeons·F SaidiM B Shadmehr
Mar 21, 1998·The British Journal of Surgery·F Sánchez-BuenoP Parrilla
May 27, 2009·Journal of Gastroenterology and Hepatology·Takaya ShimuraTakashi Joh
Mar 10, 2001·Quality in Health Care : QHC·A MelvilleA Eastwood
Nov 3, 2011·Annals of Surgical Oncology·Ye Rim ChangHan-Kwang Yang
Dec 15, 2011·Polski przeglad chirurgiczny·Tariq Al-AmawiJózef Kładny
Jul 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Bijan Moghimi-DehkordiMohammad R Zali
Nov 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Amy CollinsMark Bloomston
Mar 19, 2014·Annals of Surgical Oncology·Oh JeongSeong Yeop Ryu
Dec 22, 2005·World Journal of Surgery·Reza F SaidiNader N Hanna
Dec 20, 2015·World Journal of Surgical Oncology·Honguang ZhaoLifang Wang
Feb 24, 2009·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Oct 20, 2006·The British Journal of Surgery·S GretschelP M Schlag
Feb 18, 2006·ANZ Journal of Surgery·Inian SamarasamGeorge Mathew
Apr 13, 2012·Journal of Surgical Oncology·Jung Ho ShimKyo Young Song
Mar 5, 2014·Journal of Surgical Oncology·Ilona KeränenArto Kokkola
Sep 27, 2006·Current Problems in Surgery·Clancy J ClarkEugene Lin
Mar 3, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P KuligJ Kulig
Oct 23, 2002·The British Journal of Surgery·H H HartgrinkUNKNOWN Dutch Gastric Cancer Group
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharlene GillEric M Yoshida
May 27, 2004·World Journal of Gastroenterology : WJG·Jun TianZhen-Chun Chen
Mar 28, 2012·World Journal of Surgery·Kyung Jai KoKyo Young Song

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.