The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Takanobu YamadaHeike I Grabsch

Abstract

Previous studies comparing survival between gastric cancer (GC) patients from the West and the East were based on the assumption that background factors and prognostic factors were identical. The aim of the current study was to compare the survival of GC patients from the UK and Japan using weighted propensity score analysis after identifying all different background factors. Data from 464 patients from the Leeds Teaching Hospital NHS Trust, Leeds, UK (LTHT), and 465 patients from the Kanagawa Cancer Center Hospital, Yokohama, Japan (KCCH), who had surgery for GC were analyzed. Prognostic factors for overall survival (OS) and cancer-specific survival (CSS) were identified by univariate and multivariate analyses. Survival was compared by propensity score weighting after adjusting for all significantly different background factors. Most background factors were different between LTHT and KCCH patients. Unadjusted stage-specific OS and CSS were significantly better in KCCH. Independent prognostic factors for unadjusted OS and CSS were pT and pN in KCCH and in addition tumor location, pancreatectomy, resection margin status and number of examined lymph nodes in LTHT. Even after adjusting for all background characteristics, survival ...Continue Reading

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Citations

Nov 3, 2016·Annals of Surgical Oncology·Clifford S Cho
Nov 15, 2016·Scientific Reports·Mingming ZhangJianxin Gu
Aug 17, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorenzo FornaroAlfredo Falcone
Sep 10, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Naoki HikiSeigo Kitano
Apr 18, 2019·Journal of Psycholinguistic Research·Maha Alyami, Mohammed Ali Mohsen
Oct 21, 2017·Annals of Surgical Oncology·Vivian E StrongChang-Ming Huang
Jun 4, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·K G P KerckhoffsH I Grabsch

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