The susceptibility of a strain of Leptospira interrogans serogroup icterohaemorrhagiae to amoxycillin, erythromycin, lincomycin, tetracycline, oxytetracycline and minocycline

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
E S Broughton, L E Flack

Abstract

The failure of prophylactic penicillin to prevent a laboratory acquired case of Icterohaemorrhagiae leptospirosis prompted determination of the MIC and MBC of amoxycillin, erythromycin, lincomycin, tetracycline, oxytetracycline and minocycline for the infecting strain. Amoxycillin followed by erythromycin were the most effective, with MBCs of 0.5 mg/l after 7 days exposure and 0.1 mg/l after 21 days exposure respectively. Leptospires grew in the presence of high concentrations of tetracycline hydrochloride and oxytetracycline after prolonged incubation. This effect was less pronounced with minocycline, with MIC's of 0.025, 0.05 and 0.1 mg/l after 7, 14 and 21 days exposure respectively. The MIC of lincomycin was 0.25 mg/l at each time interval. These results support the high dose, long duration antibiotic regimens recommended in the literature.

References

Sep 21, 1985·The Veterinary Record·E S Broughton, J Scarnell
Dec 1, 1983·Antimicrobial Agents and Chemotherapy·S OieZ Yoshii
May 1, 1956·The Journal of Infectious Diseases·D G LOWC A GLEISER

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Citations

Apr 16, 2008·Antimicrobial Agents and Chemotherapy·Roseanne A RessnerClinton K Murray
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·N CíftçíogluE O Kajander
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Duane R Hospenthal, Clinton K Murray
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Clinton K Murray, Duane R Hospenthal
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Clinton K Murray, Duane R Hospenthal
Mar 1, 1988·Postgraduate Medical Journal·C F GilksC C Baker
Nov 7, 2006·International Journal of Antimicrobial Agents·Georgios Pappas, Antonio Cascio

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