The susceptibility of Atlantic salmon fry to freshwater infectious pancreatic necrosis is largely explained by a major QTL.

Heredity
R D HoustonStephen C Bishop

Abstract

Infectious pancreatic necrosis (IPN) is a viral disease with a significant negative impact on the global aquaculture of Atlantic salmon. IPN outbreaks can occur during specific windows of both the freshwater and seawater stages of the salmon life cycle. Previous research has shown that a proportion of the variation seen in resistance to IPN is because of host genetics, and we have shown that major quantitative trait loci (QTL) affect IPN resistance at the seawater stage of production. In the current study, we completed a large freshwater IPN challenge experiment to allow us to undertake a thorough investigation of the genetic basis of resistance to IPN in salmon fry, with a focus on previously identified QTL regions. The heritability of freshwater IPN resistance was estimated to be 0.26 on the observed scale and 0.55 on the underlying scale. Our results suggest that a single QTL on linkage group 21 explains almost all the genetic variation in IPN mortality under our experimental conditions. A striking contrast in mortality is seen between fry classified as homozygous susceptible versus homozygous resistant, with QTL-resistant fish showing virtually complete resistance to IPN mortality. The findings highlight the importance of t...Continue Reading

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Citations

Mar 23, 2011·Genetics, Selection, Evolution : GSE·Jørgen ØdegårdMorten Rye
May 10, 2012·Genetics, Selection, Evolution : GSE·Jørgen Ødegård, Theo H E Meuwissen
Nov 4, 2011·BMC Genomics·Silvia T Rodríguez-RamiloJesús Fernández
Oct 18, 2015·Marine Biotechnology·Peng LiuGen Hua Yue
Sep 5, 2015·Livestock Science·Stephen C Bishop, John A Woolliams
Jul 2, 2014·Journal of Immunology Research·Francesca Andreoni, Mauro Magnani
Dec 17, 2014·Frontiers in Genetics·José M YáñezScott Newman
Sep 17, 2016·Journal of Fish Diseases·Q K DoanF Allal
Nov 12, 2017·Marine Biotechnology·Eitaro SawayamaMotohiro Takagi
May 20, 2016·G3 : Genes - Genomes - Genetics·Hsin Y TsaiRoss D Houston
Sep 23, 2016·G3 : Genes - Genomes - Genetics·Christos PalaiokostasLuca Bargelloni
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Apr 18, 2020·Nature Reviews. Genetics·Ross D HoustonDiego Robledo
Sep 25, 2020·Diseases of Aquatic Organisms·Anna Maria Eriksson-KallioTuija Gadd
Dec 20, 2017·G3 : Genes - Genomes - Genetics·Grazyella M YoshidaJosé M Yáñez
Feb 22, 2017·BMC Genomics·UNKNOWN Aquaculture Genomics, Genetics and Breeding WorkshopTao Zhou
Sep 14, 2018·Frontiers in Physiology·Tao ZhouZhanjiang Liu

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