THE SUSCEPTIBILITY OF RECENT ISOLATES OF Schistosoma mansoni TO PRAZIQUANTEL

Revista Do Instituto De Medicina Tropical De São Paulo
Adriana Maria B MendonçaLuiz Carlos Alves

Abstract

Schistosomiasis is a chronic disease caused by trematode flatworms of the genus Schistosoma and its control is dependent on a single drug, praziquantel (PZQ), but concerns over PZQ resistance have renewed interest in evaluating the in vitro susceptibility of recent isolates of Schistosoma mansoni to PZQ in comparison with well-established strains in the laboratory. The in vitro activity of PZQ (6.5-0.003 µg/mL) was evaluated in terms of mortality, reduced motor activity and ultrastructural alterations against S. mansoni. After 3 h of incubation, PZQ, at 6.5 µg/mL, caused 100% mortality of all adult worms in the three types of recent isolates, while PZQ was inactive at concentrations of 0.08-0.003 µg/mL after 3 h of incubation. The results show that the SLM and Sotave isolates basically presented the same pattern of susceptibility, differing only in the concentration of 6.5 µg/mL, where deaths occurred from the range of 1.5 h in Sotave and just in the 3 h range of SLM. Additionally, this article presents ultrastructural evidence of rapid severe PZQ-induced surface membrane damage in S. mansoni after treatment with the drug, such as disintegration, sloughing, and erosion of the surface. According to these results, PZQ is very eff...Continue Reading

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Citations

Mar 23, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Thiago José Matos-RochaFábio André Brayner
Jul 12, 2019·Scientific Reports·Nattapon SimanonOnrapak Reamtong
Dec 3, 2020·Parasitology Research·Franziska WinkelmannMartina Sombetzki

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Methods Mentioned

BETA
scanning electron microscopy

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