The Sustainable Release of Vancomycin and Its Degradation Products From Nanostructured Collagen/Hydroxyapatite Composite Layers

Journal of Pharmaceutical Sciences
Tomáš SuchýFrantišek Denk

Abstract

Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine. The aim of the experiment described in this study was to develop a resorbable nanostructured composite layer with the controlled elution of antibiotics. The layer is composed of collagen, hydroxyapatite nanoparticles, and vancomycin hydrochloride (10 wt%). The stability of the collagen was enhanced by means of cross-linking. Four cross-linking agents were studied, namely an ethanol solution, a phosphate buffer solution of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide, genipin, and nordihydroguaiaretic acid. High performance liquid chromatography was used so as to characterize the in vitro release rates of the vancomycin and its crystalline degradation antibiotically inactive products over a 21-day period. The maximum concentration of the released active form of vancomycin (approximately 265 mg/L) exceeded the minimum inhibitory concentration up to an order of 17 times without triggering the burst releasing effect. At the end of the experiment, the minimum inhibitory concentration was exceeded by up to 6 times (approximately 100 mg/L). It was determined that the modifi...Continue Reading

References

Feb 1, 1992·Journal of Biomedical Materials Research·C C Chang, K Merritt
Apr 1, 1996·Biomaterials·L H Olde DaminkJ Feijen
Jan 6, 2001·Acta Orthopaedica Scandinavica·H van de BeltH J Busscher
May 19, 2004·Biomaterials·Seok Bong KimJung-Woog Shin
Sep 3, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·M StigterP Layrolle
Aug 18, 2005·Journal of Biomedical Materials Research. Part a·B P Chan, K-F So
May 3, 2006·Injury·Llinos G Harris, R Geoff Richards
Jul 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Saura C SahuMichael W O'Donnell
Jun 7, 2008·The Journal of Arthroplasty·Dirk Jan F MoojenWouter J A Dhert
Jan 21, 2012·The Korean Journal of Thoracic and Cardiovascular Surgery·Jae Suk YooSeung Hwa Choi
Jul 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Weeraphat Pon-OnI-Ming Tang

❮ Previous
Next ❯

Citations

Jan 17, 2017·Biological Trace Element Research·Yanhua WangShengmin Zhang
Oct 24, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katarzyna LeśniakAlicja Kazek-Kęsik
Dec 30, 2017·Journal of Materials Science. Materials in Medicine·G FaigleM Seidenstuecker
Nov 27, 2020·Journal of AOAC International·Patrícia Aleixa Do NascimentoHérida Regina Nunes Salgado
Jan 10, 2018·ACS Applied Materials & Interfaces·Carlos A García-GonzálezFernando J Monteiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.