The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice

FEBS Letters
Y J TzengA Graessmann

Abstract

Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period. All females are 'milk-less' and the offspring have to be nursed by foster mothers. The reason for this phenomenon is a premature apoptosis during late pregnancy. Nontheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females devlop breast cancer after the first lactation period.

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Citations

Oct 12, 2000·Free Radical Biology & Medicine·S KohlhoffM Graessmann
Aug 30, 2001·Cell Death and Differentiation·E LongX Zhao
Apr 6, 2007·International Journal of Cancer. Journal International Du Cancer·Andreas KleinAdolf Graessmann
Jul 20, 2006·Molecular Biology Reports·Xinwen WangYan Jin

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis