The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine

Expert Opinion on Biological Therapy
Yu-Chieh WangSuzanne E Peterson

Abstract

Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells. A literature survey using NCBI-PubMed and Google Scholar was performed in 2014. Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to tra...Continue Reading

References

Sep 1, 1984·Somatic Cell and Molecular Genetics·P Dráber, P Stanley
Mar 28, 2001·Science·P M RuddR A Dwek
Nov 1, 2001·Annual Review of Cell and Developmental Biology·E Saxon, C R Bertozzi
Dec 5, 2002·Current Opinion in Structural Biology·Robert S Haltiwanger
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shaolin Shi, Pamela Stanley
Jul 11, 2006·The Journal of Biological Chemistry·Laurence DuchesneDavid G Fernig
Apr 3, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hideyuki KomekadoAkira Kikuchi
Nov 21, 2007·The Journal of Biological Chemistry·Norihiko SasakiShoko Nishihara
Jan 15, 2008·Development·Penelope HaywardAlfonso Martinez Arias
Feb 19, 2008·Nature Biotechnology·Kenji OsafuneDouglas A Melton
May 21, 2008·Nature Immunology·Yvette van Kooyk, Gabriel A Rabinovich
Aug 12, 2008·Experimental Cell Research·Kai-Hsin ChangThalia Papayannopoulou
Aug 30, 2008·Nature·Franz-Josef MüllerJeanne F Loring
Oct 11, 2008·Nature Reviews. Immunology·Jamey D Marth, Prabhjit K Grewal
Jun 6, 2009·BMC Cell Biology·Tero SatomaaJarmo Laine
Aug 4, 2009·Current Opinion in Structural Biology·Dalit Shental-Bechor, Yaakov Levy
Dec 22, 2009·The Journal of Biological Chemistry·Daniel C KraushaarLianchun Wang
Feb 2, 2010·Advanced Drug Delivery Reviews·Jian Du, Kevin J Yarema
Feb 11, 2010·Future Microbiology·Christopher W ReidSusan M Twine
Apr 7, 2010·The American Journal of Pathology·Quanjian YanLan Zhou
May 15, 2010·Glycobiology·Eriko Avsar-BanYutaka Tamaru
Aug 27, 2010·The Journal of Biological Chemistry·Adam I FogelThomas Biederer
Nov 12, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anandita SethBarry D Shur
Dec 16, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masashi ToyodaAkihiro Umezawa
Apr 8, 2011·The Journal of Biological Chemistry·Hiroaki TatenoMakoto Asashima
May 17, 2011·Nature·Tongbiao ZhaoYang Xu
Jun 29, 2011·Cold Spring Harbor Perspectives in Biology·Hudson H Freeze, Bobby G Ng
Oct 11, 2011·Nature Methods·Douglas H PhanstielJoshua J Coon
Nov 19, 2011·Angewandte Chemie·Cory D RillahanJames C Paulson
Nov 24, 2011·Molecular Systems Biology·Javier MunozAlbert J R Heck

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