PMID: 6989357Jan 15, 1980Paper

The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis

The Biochemical Journal
T Yuki, R G Thurman

Abstract

Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt. nearly doubled oxygen uptake by the isolated perfused rat liver maximally after only 2.5 h of treatment (Swift Increase in Alcohol Metabolism). Inhibition of enhanced oxygen uptake by KCN (2mM) and 4-methylpyrazole (0.8 mM) suggested the involvement of the mitochondrial respiratory chain and alcohol dehydrogenase in this phenomenon. Glycolysis was depressed after ethanol treatment. Diminished ATP generation via glycolysis accounts for a portion (23-50%) of the increased oxygen uptake, assuming that other rates of biosynthesis remain constant. Injection of adrenaline (2 mg/kg) 1 h before perfusion mimicked partially the action of ethanol on hepatic oxygen uptake. The increases produced by ethanol and adrenaline were not additive, suggesting that adrenaline is involved in the action of ethanol. Moreover, the increase in hepatic oxygen uptake produced by 2.5 h of ethanol treatment could be blocked by either alpha-(phenoxybenzamine; 40 mg/kg) or beta-(propranolol; 40 mg/kg) adrenergic blocking agents. Blood glucose increased after ethanol treatment, supporting the involvement of glycogenolytic hormones in this effect. These data indicate that at least ...Continue Reading

Citations

Jan 1, 1988·Experimental Pathology·J K Baruah, D Kinder
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·T YukiR G Thurman
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·S JiR G Thurman
Nov 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bharath Nath, Gyongyi Szabo
Apr 23, 2009·Alcoholism, Clinical and Experimental Research·Akiko ShimamotoTatsuya Fujimiya
Jan 27, 2005·Alcohol·Zhi Zhong, John J Lemasters
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber
Dec 13, 2005·Free Radical Biology & Medicine·Jian Zhuge, Arthur I Cederbaum
Jan 1, 1993·Journal of Hepatology·P MacMathunaR Williams
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tetsuya YamamotoSumio Takahashi
Dec 1, 1990·Biochemical Pharmacology·E MezeyB E Akinshola
Nov 9, 2000·Biochimica Et Biophysica Acta·R CariniE Albano
Jun 22, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tetsuya YamamotoYuji Moriwaki
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·J J LemastersR G Thurman
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B E AkinsholaE Mezey
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Tsukamoto, X P Xi
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Blair U Bradford
Jan 1, 1987·Annals of the New York Academy of Sciences·Y Israel, H Orrego
Jul 23, 2005·International Journal of Toxicology·Kallirroe ZiavrouTheodore G Vougiouklakis
Aug 19, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael M ChenElizabeth J Kovacs
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HelzbergE R Gordon
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J N Benoit, D N Granger
May 12, 2000·Environmental Health Perspectives·G M PastinoM Carroquino
Jan 1, 1988·Annals of the New York Academy of Sciences·R G ThurmanJ L Lemasters
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D M GilliamA C Collins
Jan 1, 1995·Journal of Gastroenterology and Hepatology·R G ThurmanJ J Lemasters
Nov 5, 2008·Archives of Pharmacal Research·S M Lee, T S Cho
Jan 1, 1995·Digestive Diseases and Sciences·B E VictorT A Miller
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·K E Kitson
Aug 1, 1989·Alcoholism, Clinical and Experimental Research·R G ThurmanE Glassman
Apr 1, 1988·Alcoholism, Clinical and Experimental Research·H SpeiskyK O Lindros
Jan 1, 1992·Critical Reviews in Clinical Laboratory Sciences·S W French
Mar 8, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claudia von MontfortGavin E Arteel
Sep 28, 2010·Biological Chemistry·Juliane I Beier, Craig J McClain
Jan 1, 2010·Digestive Diseases·Gavin E Arteel
Jan 1, 1985·Reviews on Drug Metabolism and Drug Interactions·K E Crow
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Brian J DewarRonald G Thurman
Oct 2, 1998·The American Journal of Physiology·R G Thurman

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