The swinging pendulum of cancer immunotherapy personalization

Personalized Medicine
Tara S Abraham, Adam E Snook

Abstract

Cancer immunotherapy has long offered the promise of producing cancer treatments that are more effective and less toxic than traditional chemotherapy and radiotherapy. That potential has only begun to be realized in the last 5 years with the first US FDA-approved cancer vaccine (sipuleucel-T), checkpoint inhibitors and adoptive cell therapy. While these therapies have been remarkably more effective than previous cancer immunotherapeutics, they are often limited by their inherently personalized nature. Indeed, each patient's immune system and cancer are unique, limiting the scalability and generalizability of new approaches. However, emerging solutions may overcome these limitations, producing 'off-the-shelf' cancer immunotherapies that transform patient outcomes.

References

Jul 1, 1994·The Journal of Experimental Medicine·A N Houghton
Mar 22, 1996·Science·D R LeachJ P Allison
May 22, 2001·Stem Cells·J S OdoricoJ A Thomson
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Torsten DreierPatrick A Baeuerle
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elfriede NoessnerRolf D Issels
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janet E BuhlmannArlene H Sharpe
Aug 17, 2004·Cancer Immunology, Immunotherapy : CII·Luisa NovellinoGiorgio Parmiani
Feb 14, 2006·Journal of Immunological Methods·William Y HoPhilip D Greenberg
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cor H J LamersEgbert Oosterwijk
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly E BeckJames C Yang
Sep 2, 2006·Science·Richard A MorganSteven A Rosenberg
Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julie R ParkMichael C Jensen
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Junzo HamanishiShingo Fujii
Sep 28, 2007·Clinical Pharmacology and Therapeutics·A E SnookS A Waldman
Nov 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie G DowneySteven A Rosenberg
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chrysoula I LiakouPadmanee Sharma
Oct 11, 2008·Science·Kajsa WingShimon Sakaguchi
Dec 20, 2008·Expert Review of Vaccines·Philippe Fournier, Volker Schirrmacher
Mar 31, 2009·Current Opinion in Immunology·Michel SadelainIsabelle Rivière
Dec 17, 2009·The Journal of Experimental Medicine·Loise M FranciscoArlene H Sharpe
Dec 18, 2009·Nature Immunology·Harald von Boehmer, Fritz Melchers
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip W KantoffWayne R Godfrey
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Dec 16, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria R ParkhurstSteven A Rosenberg
Apr 8, 2011·The New England Journal of Medicine·James D Chambers, Peter J Neumann
Apr 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven A RosenbergMark E Dudley

❮ Previous
Next ❯

Citations

Jun 12, 2019·Journal of Dental Education·Linda Y ZhengSteven D London

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
xenograft

Software Mentioned

Immunoscore

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Brain Sciences
Elias J Sayour, Duane A Mitchell
Texas State Journal of Medicine
P V LEMKAU
JAMA Surgery
Bonnie Sun, Michael E Zenilman
Journal of the Advanced Practitioner in Oncology
Elizabeth S Waxman, Frank V Fossella
© 2022 Meta ULC. All rights reserved