The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans.

FEBS Letters
Xuming MaoJiangye Chen

Abstract

The ability of dimorphic transition between yeast and hyphal forms in Candida albicans is one of the vital determinants for its pathogenicity and virulence. We isolated C. albicans SWI1 as a suppressor of the invasive growth defect in a Saccharomyces cerevisiae mutant. Expression of C. albicans SWI1 in S. cerevisiae partially complemented the growth defect of a swi1 mutant in the utilization of glycerol. Swi1 is in a complex with Snf2 in C. albicans, and both proteins are localized in the nucleus independent of the growth form. Deleting SWI1 or SNF2 in C. albicans prevented true hyphal formation and resulted in constitutive pseudohypha-like growth in all media examined. Furthermore, swi1/swi1 mutant was defective in hypha-specific gene expression and avirulent in a mouse model of systemic infection. These data strongly suggest the conserved Swi/Snf complex in C. albicans is required for hyphal development and pathogenicity.

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Citations

Mar 7, 2008·Molecular Biology of the Cell·Sophie GoyardChristophe d'Enfert
Aug 24, 2007·Eukaryotic Cell·Yandong LiJiangye Chen
Mar 20, 2012·Research in Microbiology·Marta RieraGuilhem Janbon
Sep 6, 2011·Biochimica Et Biophysica Acta·Jessica Lopes da Rosa, Paul D Kaufman
Jun 15, 2007·Trends in Genetics : TIG·Chang Seob Kwon, Doris Wagner
Jun 9, 2015·Trends in Genetics : TIG·Malcolm WhitewayRoberto Rodríguez-Ortiz
Jun 20, 2008·FEMS Microbiology Letters·Xuming MaoJiangye Chen
Oct 10, 2015·FEMS Yeast Research·Sushmita Roy, Dawn Thompson
Jan 26, 2020·FEMS Yeast Research·Sonia VillaShankar Thangamani
Jul 7, 2009·Acta Biochimica Et Biophysica Sinica·Xuming MaoJiangye Chen
Nov 29, 2016·Biotechnology for Biofuels·Shizeng WangQipeng Yuan

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