The switch from Gd-DTPA to Gd-DOTA is not associated with decrease of the T1 signal intensity of the pallidus and dentate in a pediatric population.

Acta Radiologica
Pietro GulinoMario Mascalchi

Abstract

The switch from the linear gadolinium-based contrast agent (GBCA) gadopentate dimeglumine (Gd_DTPA) to the macrocyclic GBCA gadobutrol is associated with a decrease of the T1 signal intensity (SI) in brain gray matter nuclei. The effects of the switch to other macrocyclic GBCAs are not yet established. To explore the effects of switching from Gd-DTPA to the macrocyclic GBCA gadoterate meglumine (Gd-DOTA) in pediatric patients. We measured the pallidus/middle cerebellar peduncle (MCP) SI ratio and the dentate/MCP SI ratio in pre-contrast sagittal T1-weighted spin-echo images in nine patients who had received ≥6 administrations of Gd-DTPA and then of Gd-DOTA, in 18 patients who had received ≥6 administrations of Gd-DOTA alone, and in nine age-matched controls without prior GBCA administrations. Serial assessment was performed in patients who switched from Gd-DTPA to Gd-DOTA. Finally, the rate of change of pallidal/MCP and dentate/MCP SI ratios between the first and last Gd-DOTA administrations was compared. The pallidal/MCP and dentate/MCP SI ratios were (P < 0.05) higher in patients with prior Gd-DTPA and Gd-DOTA administrations compared to the controls. After the switch, the pallidal/MCP SI ratio increased in nine patients and ...Continue Reading

References

Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Aug 22, 2015·AJNR. American Journal of Neuroradiology·M E AdinD M Yousem
Dec 15, 2015·AJNR. American Journal of Neuroradiology·J RamalhoM Castillo
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Jun 28, 2017·Lancet Neurology·Vikas GulaniUNKNOWN International Society for Magnetic Resonance in Medicine
Jul 22, 2017·Journal of Magnetic Resonance Imaging : JMRI·Simona BussiFederico Maisano
Nov 11, 2018·European Radiology·Carlo C QuattrocchiUNKNOWN GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology
Oct 31, 2019·Journal of Magnetic Resonance Imaging : JMRI·Elif Dilara TopcuogluYasar Bukte

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