The sympathetic nervous response in inflammation

Arthritis Research & Therapy
Georg Pongratz, Rainer H Straub

Abstract

Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of this review provides the reader with an overview showing that the interaction of the SNS with the immune system to control inflammation is strongly context-dependent (for example, depending on the activation state of the immune cell or neuro-transmitter concentration). In the second part we focus on autoimmune arthritis as a well investigated example for sympathetically controlled inflammation to show that the SNS and catecholamines play a differential role depending on the time point of ongoing disease. A model will be developed to explain the proinflammatory effects of the SNS in the early phase and the anti-inflammatory effects of catecholamines in the later phase of autoimmune arthritis. In the final part, a conceptual framework is discussed that shows that a major purpose of increased SNS activity is nourishment of a continuously activated immune system at a systemic level using energy-rich fuels (glucose, amino acids, lipids), while uncoupling from central nervous regulation occurs at sites of inflammation by repulsion of sympat...Continue Reading

References

Nov 1, 1992·Annals of the Rheumatic Diseases·B L KiddD R Blake
Jan 1, 1991·Circulation Research·C P SungG Z Feuerstein
Mar 1, 1991·Gastroenterology·M G SwainS M Collins
Jan 1, 1995·Stroke; a Journal of Cerebral Circulation·E TarkowskiA Tarkowski
Apr 1, 1994·Annals of the Rheumatic Diseases·P I MappD R Blake
Jul 31, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M MerhiZ Khalil
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E MillerR H Straub
Dec 20, 2000·Brain, Behavior, and Immunity·D S Ramer-QuinnV M Sanders
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A SwansonV M Sanders
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph R Podojil, Virginia M Sanders
Jul 16, 2003·Journal of Neurochemistry·Wei LiBeth A Habecker
Dec 1, 1962·Annals of the Rheumatic Diseases·M THOMPSON, E G BYWATERS
Jul 14, 2004·Neuroimmunomodulation·Reiner OberbeckMichael S Exton
Feb 9, 2006·Autonomic Neuroscience : Basic & Clinical·Paul R SaundersKevan Jacobson
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georg PongratzVirginia M Sanders
May 1, 2007·Brain, Behavior, and Immunity·Dwight M Nance, Virginia M Sanders
May 12, 2007·Brain, Behavior, and Immunity·Edith Chen, Gregory E Miller
May 16, 2007·The Journal of Experimental Medicine·Tobias BoppEdgar Schmitt
Oct 5, 2007·Nature·Michael A FlierlPeter A Ward
Jan 22, 2008·Experimental Dermatology·Earl GoyartsRichard D Granstein
Sep 30, 2008·Arthritis and Rheumatism·Adriana del ReyRainer H Straub
Nov 15, 2008·Journal of Hypertension·Maritta K Pöyhönen-AlhoRisto J Kaaja

❮ Previous
Next ❯

Citations

Jul 15, 2015·Expert Review of Clinical Immunology·Torsten Lowin, Rainer H Straub
Apr 8, 2016·Journal of the American Society of Hypertension : JASH·Guido Grassi, Venkata S Ram
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V GunterbergH Strid
Sep 10, 2016·Journal of Neuroimmunology·Jorge Barrios-PayánRogelio Hernandez-Pando
Jul 23, 2016·Journal of the American College of Cardiology·Mingxian ChenShenghua Zhou
Nov 5, 2016·European Journal of Pharmacology·Jocelyn Fotso SohReza Tabrizchi
Nov 2, 2016·PloS One·Cecília J AlvesMeriem Lamghari
Nov 20, 2016·Journal of Biomedical Materials Research. Part a·Josh D Erndt-Marino, Mariah S Hahn
May 12, 2017·International Journal of Molecular Sciences·Gaetana MinnoneLuisa Bracci-Laudiero
Jun 1, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A L CerviA E Lomax
Mar 18, 2016·Therapeutic Advances in Cardiovascular Disease·Erin B Taylor, Michael J Ryan
May 16, 2018·Nature Reviews. Nephrology·Tao YangMohan K Raizada
Feb 12, 2019·Journal of Neuroscience Research·K Duris, M Jurajda
Dec 24, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Davide MartelliRobin M McAllen
Feb 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiaoquan RaoSanjay Rajagopalan
Nov 13, 2018·Anesthesiology·Heberto Suarez-RocaWilliam Maixner
Feb 5, 2019·British Journal of Pharmacology·Erin B TaylorMichael J Ryan
Mar 26, 2019·Behavioral Medicine·Nadya DichStacey N Doan
May 16, 2019·American Journal of Physiology. Renal Physiology·Sally M SalahKatherine I Swenson-Fields
Mar 29, 2019·Current Opinion in Rheumatology·Torsten LowinGeorg Pongratz
Feb 14, 2020·BMC Medicine·Konstantinos IoannidisAnne-Laura van Harmelen
Jun 14, 2020·International Journal of Environmental Research and Public Health·Denisa MarginăAristidis Tsatsakis
Apr 6, 2018·International Journal of Molecular Medicine·Xianliang DaiChun Liang
Sep 1, 2020·Journal of the American Heart Association·Ting-Tse LinShien-Fong Lin
Jun 29, 2016·Clinical & Translational Immunology·Tae-Hyung KimErica K Sloan
Sep 8, 2015·Arthritis Research & Therapy·Torsten Lowin, Rainer H Straub
Sep 4, 2016·Arthritis Research & Therapy·Aikaterini ThanouJoan T Merrill
Dec 23, 2017·Frontiers in Immunology·Donald B HooverDavid L Williams
Nov 10, 2018·Nature Reviews. Cardiology·Eleonora TobaldiniNicola Montano
Mar 5, 2019·The Journal of Clinical Investigation·Hiroki Kabata, David Artis
Mar 9, 2020·Journal of Neuroinflammation·Yajing WeiShuzhong Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.