The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea

Journal of Thoracic Disease
Valeria BisogniGian Paolo Rossi

Abstract

Obstructive sleep apnoea (OSA) is the most common sleep disorder of breathing in middle-aged and overweight subjects. It features recurrent episodes of upper airway total (apnoea) o partial (hypopnea) collapse during sleep, which are associated with a reduction in blood oxygen saturation and with arousal from sleep to re-establish airway patency. An association of OSA with dysregulation of the autonomous nervous system (ANS) and altered catecholamines (CAs) metabolism has been contended for years. However, the pathophysiology mechanisms underlying these alterations remain to be fully clarified. Nonetheless, these alterations are deemed to play a key pathogenic role in the established association of OSA with several conditions besides arterial hypertension (HT), including coronary artery disease, stroke, and, more in general, with increased risk of cardiovascular (CV) events. Hence, in this review we will analyse the relationship between the sleep disturbances associated with OSA and the altered function of the ANS, including CAs metabolism.

Citations

Nov 11, 2017·F1000Research·Charlotte Van HerzeeleKristian Vinter Juul
Feb 23, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johanna RocheFabienne Mougin
Dec 19, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hong XieJuan Bai

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