PMID: 2478811Jan 1, 1989Paper

The sympathetic nervous system in heart failure.

Journal of Cardiovascular Pharmacology
J N Cohn

Abstract

The syndrome of clinical heart failure (CHF) is characterized by increased activity of the sympathetic nervous system (SNS), which may contribute in part to the heightened vascular tone that adversely affects left ventricular systolic performance. The increased resting SNS activity is accompanied by an attenuated SNS response to physiological stress, including orthostasis, hypotension, and maximal exercise. Since heart transplantation appears to reverse the increased resting activity and the deficient reflex responsiveness, these abnormalities appear to be functional. The degree of SNS activation appears to be directly related to mortality in CHF, thus suggesting that heightened SNS activity is either a marker or a risk factor for a lethal outcome in this syndrome. Pharmacologic inhibition of the SNS is an attractive therapeutic option for evaluation in CHF.

Citations

Jan 1, 1995·Journal of the American College of Cardiology·M BöhmE Erdmann
Mar 15, 2012·Journal of Natural Medicines·Bhulan Kumar SinghSyed Ehtaishamul Haque
May 27, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Miyuki AndoMasunori Matsuzaki
Aug 1, 1991·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F LeddaL Mantelli
May 9, 1998·Journal of Cardiac Failure·J Silva-CardosoM Cerqueira-Gomes
Nov 4, 2006·Pharmacology & Therapeutics·Sian E HardingJulia Gorelik
Jul 16, 2013·Autonomic Neuroscience : Basic & Clinical·Heow Won LeePan Dong Ryu
Apr 2, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Makoto AndoMitsuhiro Yokoyama
Apr 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Per Reidar WoldbaekTheis Tønnessen

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