The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

Acta Physiologica
Anna C Z RodriguesOsvaldo Delbono

Abstract

Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function. Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy-1 mice. We found that the SNS regulates motor nerve synaptic vesicle release, skeletal muscle transcriptome, muscle force generated by motor nerve activity, axonal neurofilament phosphorylation, myelin thickness, and myofibre subtype composition and CSA. The SNS also modulates the levels of postsynaptic membra...Continue Reading

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Citations

Jul 7, 2019·Journal of Cellular and Molecular Medicine·Caroline LeonelAlexander Birbrair
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Mar 20, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yi ZhangChang-Qing Guo
Jul 25, 2019·Progress in Biophysics and Molecular Biology·Anna Di BonaTania Zaglia
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sunmin ParkSong Mee Cho
Sep 6, 2020·Molecular and Cellular Neurosciences·Andrei TsentsevitskyEllya Bukharaeva
May 1, 2021·International Journal of Molecular Sciences·Ellya BukharaevaAndrei Tsentsevitsky
May 23, 2021·The Journal of Physiological Sciences : JPS·Harumi HottaKazuhiro Shigemoto

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