PMID: 38359Jun 15, 1979

The sympathetic neuron: regulation mechanisms for transmitter synthesis, transmitter release, and stimulus response (author's transl)

Klinische Wochenschrift
G Hertting

Abstract

A great multitude of factors acting at different sites of the afferent sympathetic nerve are capable to modify the magnitude of its stimulus-induced effects. 1) Specific receptors, located at the ganglionic synapse display inhibitory of facilitatory effects on the ganglionic transmission of the nerve impulse. 2) The rate of synthesis of the neurotransmitter noradrenalin is regulated at the level of the tyrosine hydroxylase. Transsynaptic mechanisms adapt the rate of synthesis of noradrenalin to nerve activity and transmitter release. 3) The amount of transmitter released per nerve impulse is controlled by a variety of receptors located presumably presynaptically at neuronal sites. Inhibitory and facilitatory "auto"-receptors stimulated by the released transmitter itself represent a local feed-back control. Similarly receptors for transmitters of cholinergic or serotoninergic neurons as well as autacoid hormones are involved in the local control of noradrenalin release. In addition, kinines, prostaglandins, or compounds like adenosine, some of them released from the target cells by the sympathetic stimuli or delivered by the blood stream are involved in the modulation of stimulus-evoked noradrenalin release. 4) Stimulus response...Continue Reading

References

Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·U Otten, H Thoenen
Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·A JobkeG Hertting
Mar 29, 1972·Nature: New Biology·P Hedqvist, U S von Euler

Related Concepts

Kinins
Synaptic Transmission
Norepinephrine, (+, -)-Isomer
Prostaglandins
Norepinephrine Receptors
Cholinergic Receptors
Receptors, Tryptamine
Sympathetic Nervous System
Tyrosine 3-Monooxygenase
Neurosteroids

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