PMID: 9651662Jul 4, 1998Paper

The sympathetic skin response in peripheral autonomic failure--evaluation in pure failure, pure cholinergic dysautonomia and dopamine-beta-hydroxylase deficiency

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
F MagnificoC J Mathias

Abstract

The sympathetic skin response (SSR) detects changes in the electrical potential in the skin in response to physiological and electrical stimuli and, therefore, may indicate the integrity of sympathetic cholinergic neural pathways to sweat glands. This has been evaluated in 21 patients with three forms of peripheral autonomic failure. Of these, 15 had pure autonomic failure (PAF) without additional neurological features; investigations indicated both sympathetic and parasympathetic failure. Four patients had pure cholinergic dysautonomia (PCD), with clinical and laboratory features indicating only cholinergic failure. Two siblings had dopamine-beta-hydroxylase (DBH) deficiency with only sympathetic adrenergic failure. None was on drugs affecting cholinergic function. Ten normal individuals were aged-matched with PAF patients and studied as controls. The SSR was recorded from the palmar hand and plantar foot surfaces, using previously described techniques, in response to physiological (auditory, cough and inspiratory gasp) and electrical stimuli. Nerve conduction studies excluded an associated motor or sensory neuropathy. The SSR was present in all normal individuals, and in both patients with DBH deficiency who had preserved cho...Continue Reading

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Citations

Feb 24, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D S Goldstein, C Tack
May 10, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Martin A Goldstein, Michael E Silverman
Mar 21, 2013·Autonomic Neuroscience : Basic & Clinical·Juan IdiaquezGiuseppe Lauria
Mar 18, 2003·Journal of the Neurological Sciences·Y L LoC E Tan
May 3, 2003·NeuroImage·Hugo D CritchleyRaymond J Dolan
Oct 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P CarigaP H Ellaway
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Christopher J Mathias
Dec 18, 2009·Cognitive Neuropsychiatry·Max ColtheartJohn Sutton
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·P CarigaP H Ellaway
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·Christopher J Mathias
Aug 25, 2010·Annual Review of Psychology·Max ColtheartRyan McKay
Apr 22, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Masato AsahinaShigeki Hirano
May 31, 2014·Journal of Neurotrauma·Michael J BergerAndrei V Krassioukov
Feb 5, 2010·Autonomic Neuroscience : Basic & Clinical·P H EllawayC J Mathias
Jul 15, 2016·British Journal of Neurosurgery·Kumbhar Kartik RevanappaVedantam Rajshekhar
Feb 15, 2001·Nature Neuroscience·H D CritchleyR J Dolan
Apr 16, 2010·Annals of the New York Academy of Sciences·Max Coltheart
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Luis E OkamotoItalo Biaggioni
Jan 27, 2004·Journal of Applied Physiology·J Clayton FinleyWarren Lockette
Oct 10, 2020·Journal of Inherited Metabolic Disease·Tessa WassenbergMichèl A Willemsen

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