The synaptic action of Degenerin/Epithelial sodium channels

Channels
Alexis Hill, Yehuda Ben-Shahar

Abstract

Degenerin/Epithelial Sodium Channels (DEG/ENaCs) are a large family of animal-specific non-voltage gated ion channels, with enriched expression in neuronal and epithelial tissues. While neuronal DEG/ENaCs were originally characterized as sensory receptor channels, recent studies indicate that several DEG/ENaC family members are also expressed throughout the central nervous system. Human genome-wide association studies have linked DEG/ENaC-coding genes with several neurologic and psychiatric disorders, including epilepsy and panic disorder. In addition, studies in rodent models further indicate that DEG/ENaC activity in the brain contributes to many behaviors, including those related to anxiety and long-term memory. Although the exact neurophysiological functions of DEG/ENaCs remain mostly unknown, several key studies now suggest that multiple family members might exert their neuronal function via the direct modulation of synaptic processes. Here, we review and discuss recent findings on the synaptic functions of DEG/ENaCs in both vertebrate and invertebrate species, and propose models for their possible roles in synaptic physiology.

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Citations

Dec 17, 2020·Journal of Neurogenetics·Umar Al-Sheikh, Lijun Kang
Feb 26, 2021·Journal of Neurogenetics·Ross M McKinneyYehuda Ben-Shahar
Feb 9, 2019·G3 : Genes - Genomes - Genetics·Laura Faith GeorgeEmily Anne Bates
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Giuseppe MontalbanoAntonino Germanà
Nov 9, 2021·Journal of Neuroscience Research·Rosaria FormisanoHarbinder S Dhillon

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Methods Mentioned

BETA
transgenic
immunoprecipitation

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