The synaptic connectivity that underlies the noxious transmission and modulation within the superficial dorsal horn of the spinal cord

Progress in Neurobiology
Shengxi WuYunqing Li

Abstract

Noxious stimuli can usually cause the aversive sensations, pain and itch. The initial integration of such noxious information occurs in the superficial dorsal horn of the spinal cord (SDH), which is very important for understanding pain sensation and developing effective analgesic strategies. The circuits formed by pools of neurons and terminals within SDH are accepted as the platform for such complicated integrations and are highly plastic under conditions of inflammatory or neuropathic pain. Recent literature offers a complicated, yet versatile view of SDH intrinsic circuits with both inhibitory and excitatory components. However, our knowledge about the adaptative regulation of SDH local circuits is still far from sufficient due to the incomplete understanding of their organization as they are intermingled with primary afferent fibers (PAFs), poorly understood or identified SDH neurons, somehow contradictory data for descending control systems. A more positive view emphasizes abundant modern data on SDH neuron morphology and physiology riding on the back of significant technological advancements used in neuroscience. Reviewing the current literature on this topic thus produced an integrated understanding of SDH neurons and t...Continue Reading

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Citations

Oct 10, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Nejada DinguGiuliano Taccola
Mar 14, 2012·Current Opinion in Neurobiology·Steven A Prescott, Stéphanie Ratté
Apr 23, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Jeffrey E ArleJay L Shils
Aug 1, 2019·European Journal of Oral Sciences·Sixin LiuWenli Lai
Aug 26, 2020·The Journal of Clinical Investigation·Jun-Bin YinYun-Qing Li

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