The synchronization of the human cortical working memory network

NeuroImage
Sharlene D NewmanPatricia A Carpenter

Abstract

A verbal reasoning problem at the intersection of verbal working memory, problem-solving, and language comprehension was examined using event-related fMRI to distinguish differences in the differential timing of the response of the various cortical regions that compose the working memory network. Problems were developed such that the process demand as well as the timing of the manipulation of the contents of working memory (i.e., a demanding computation) was varied. Activation was observed in several regions including the dorsolateral prefrontal cortex, the inferior frontal gyrus, and the parietal lobe. Examination of the MR amplitude response revealed that the regions do not all activate simultaneously; instead, their activation time courses reveal differential responses that correspond to their theoretical processing role in the problem-solving task. The coordination of cortical area responses reveals how the various cortical regions synchronize and collaborate in order to accomplish a given cognitive function.

References

Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jun 1, 1996·Neuropsychologia·S C BakerT W Robbins
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Dec 22, 1999·Journal of Cognitive Neuroscience·B R Postle, M D'Esposito
Oct 1, 1992·Journal of Cognitive Neuroscience·J RademacherV S Caviness

❮ Previous
Next ❯

Citations

Jun 3, 2009·Journal of Cognitive Neuroscience·Joaquín M Fuster
Mar 9, 2013·Journal of Cognitive Neuroscience·Maite Crespo-GarciaMercedes Atienza
Feb 25, 2003·Human Brain Mapping·Jack GandourXiaojian Li
Aug 25, 2004·NeuroImage·Jackson GandourMark Lowe
Feb 24, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Steven L Bressler, Emmanuelle Tognoli
Nov 22, 2005·Brain and Language·Kathleen AhrensYuan-Yu Hsu
Mar 4, 2015·Journal of Experimental Child Psychology·H Lee SwansonCatherine M Lussier
Oct 20, 2009·Arquivos de neuro-psiquiatria·Fernanda Chapchap Martins, Karin Zazo Ortiz
Jul 2, 2005·American Journal of Speech-language Pathology·Heather Harris Wright, Rebecca J Shisler
Aug 23, 2007·Neuroreport·Vincent J SchmithorstElena Plante
Nov 13, 2007·Cognitive, Affective & Behavioral Neuroscience·Marcel Adam Just, Sashank Varma
Jun 25, 2003·Neuroreport·Sean P A DrummondJennifer S Salamat
Dec 10, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sayed Ausim Azizi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.