PMID: 9438646Jan 23, 1998Paper

The syndrome of autoimmune interstitial nephritis and membranous nephropathy

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
W R GriswoldH Spiegelberg

Abstract

A 2-year-old male patient was evaluated for Fanconi syndrome with hypertension and failure to thrive. Renal biopsy revealed autoimmune interstitial nephritis with membranous nephropathy. The patient developed autoimmune hemolytic anemia and intractable diarrhea with villous atrophy of the jejunum. He progressed to end-stage renal disease and was transplanted without recurrent disease. Immune work-up done prior to immunosuppressive therapy showed marked elevation of IgE. Studies of T lymphocyte cytokine production showed normal production of interleukin-4 but depressed levels of interferon-gamma. The simultaneous occurrence of autoimmune interstitial nephritis and membranous nephropathy in a young male represents a unique syndrome. Abnormalities of T lymphocyte subpopulations and their cytokines may be involved in the pathogenesis of this disorder.

Citations

Apr 15, 1999·Current Opinion in Pediatrics·R W Chesney
Feb 4, 2014·The Journal of Rheumatology·Gustavo Martelli PalominoEduardo A Donadi
Jul 17, 2018·Cognitive Research: Principles and Implications·Jennifer M McCafferyA Mike Burton

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