The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53

Mechanisms of Ageing and Development
Deping XuHaisheng Zhou

Abstract

Cardiovascular calcification is associated with cardiovascular morbidity and mortality of patients with end-stage renal diseases (ESRD). Hyperphosphatemia and many of the inflammatory markers and mediators, including interleukin-6 (IL-6), are considered as the major risk factors of cardiovascular calcification. Although cellular senescence may be involved in cardiovascular calcification caused by phosphate overload and (or) IL-6 in patients with ESRD, less is known about the underlying mechanisms for phosphate- and IL-6-induced senescence-associated calcification of vascular smooth muscle cells (VSMCs). In the present study, we investigated the correlation between cellular senescence and vascular calcification induced by loading phosphate and (or) IL-6 in VSMCs. Our findings show that p53 plays a major role in senescence-associated vascular calcification induced by phosphate overload. IL-6 induces senescence-associated calcification in VSMCs depending upon activation of the IL-6/soluble IL-6 receptor (sIL-6R)/signal transducer and activator of transcription 3 (STAT3)/p53/p21 pathway. We demonstrate that the synergistic action of phosphate overload and IL-6 enhances senescence-associated calcification in a p53-dependent manner a...Continue Reading

References

Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T M JohnsonT Finkel
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Apr 17, 2004·Kidney International·Ali A HaydarDavid J A Goldsmith
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Ittai Ben-Porath, Robert A Weinberg
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Jan 27, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mohammed S RazzaqueBeate Lanske
Nov 11, 2006·Circulation Research·Rebecca C JohnsonJoseph Loscalzo
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliFrancesca Mallamaci
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Oct 13, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziyad Al-AlyDwight A Towler
May 2, 2008·Kidney International·Keith A HruskaRaymond Pratt
Nov 5, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mahmut CivilibalNil Arisoy
Nov 27, 2008·The Journal of Clinical Investigation·L Darryl Quarles
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ritsuko Nakano-KurimotoHiroaki Matsubara
Oct 17, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Satoko NakamuraYuhei Kawano
Dec 18, 2009·Kidney International·Daniela V BarretoUNKNOWN European Uremic Toxin Work Group (EUTox)
Feb 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohamed M NasrallahUsama A A Sharaf El Din
Jul 2, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Aya TakemuraYasuyoshi Ouchi
Sep 3, 2011·Circulation Research·Catherine M ShanahanCecilia M Giachelli
Jan 15, 2014·JAK-STAT·Hirotada KojimaKoichi Nakajima
Nov 29, 2014·American Journal of Hypertension·Mohsen AgharaziiDarren E Richard
Dec 18, 2015·Methods in Molecular Biology·Edward R Smith
Feb 4, 2016·Acta Biochimica Et Biophysica Sinica·Pan ZhaoXuejun Zhang
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group
Nov 24, 2017·Journal of the American Society of Nephrology : JASN·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Dec 21, 2017·The Journal of Investigative Dermatology·Zhenzhen TuLiangdan Sun
Feb 9, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lucie Hénaut, Ziad A Massy
Apr 17, 2019·Contributions to Nephrology·Kosaku NittaKen Tsuchiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

© 2021 Meta ULC. All rights reserved