The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay

Molecular Endocrinology
S MiccadeiD Civitareale

Abstract

The transcription factors, thyroid transcription factor 1 (TTF-1) and Pax 8, play a pivotal role in the transcriptional regulation of the thyroid differentiation marker genes and in the differentiation of the thyroid follicular cells. They have a very restricted tissue distribution, and the thyrocyte is the only cell type with the simultaneous expression of these factors. Here we show that TTF-1 and Pax 8 cooperatively activate their target genes and that their synergistic activity requires the cross-talk between enhancer and gene promoter. We have characterized the cis and trans requirements of the TTF1/Pax 8 synergistic activity on the thyroperoxidase gene. We show that their synergy is also important for thyroglobulin gene transcription.

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Citations

Dec 4, 2003·Molecular and Cellular Biology·Cindy J BachurskiDihua Hong
Apr 26, 2012·BMC Genomics·Sergio Ruiz-LlorentePilar Santisteban
Feb 6, 2017·Molecular and Cellular Endocrinology·Denise P Carvalho, Corinne Dupuy
Jul 12, 2005·Oncogene·Stefania MiccadeiDonato Civitareale
Aug 20, 2010·Clinical Endocrinology·Tina Di PalmaMariastella Zannini
Oct 7, 2004·Endocrine Reviews·Mario De Felice, Roberto Di Lauro
Feb 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Eleonora BorboneValerio Orlando
Aug 26, 2020·The Journal of Clinical Endocrinology and Metabolism·Megumi Iwahashi-OdanoSatoshi Narumi
Aug 31, 2016·International Journal of Oncology·Célia DupainLiliane Massaad-Massade

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