PMID: 3750792Aug 2, 1986Paper

The synergistic activity of tiamulin and chlortetracycline: in-feed treatment of bacterially complicated enzootic pneumonia in fattening pigs

The Veterinary Record
D G BurchR E Tuck

Abstract

The antibacterial effects of a combination of tiamulin and chlortetracycline in vitro against a number of field isolates of Pasteurella multocida, Haemophilus pleuropneumoniae and Bordetella bronchiseptica were examined. There was a marked synergism between the two antibiotics against all eight isolates of P multocida, against seven of nine isolates of H pleuropneumoniae and against the single strain of B bronchiseptica tested. Two field trials were carried out on a herd with a history of complicated enzootic pneumonia where the presence of Mycoplasma hyopneumoniae and P multocida had been established and subsequently the presence of H pleuropneumoniae was discovered. Feed containing tiamulin at 100 ppm combined with chlortetracycline at 300 ppm was given for seven days to pigs affected with pneumonia, and the results were compared with untreated controls and pigs receiving chlortetracycline at 300 ppm. There was a follow-up observation period of three weeks when all groups received unmedicated feed. During the medication period the combination treated groups showed a statistically significant increase in average daily weight gain of 156 g (20.4 per cent) and in feed conversion efficiency of 0.576 (20.8 per cent) and a numerica...Continue Reading

Citations

May 6, 2003·Bioorganic & Medicinal Chemistry Letters·Dane M SpringerRamesh N Patel
Jun 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·Y UedaK Takeda
Jul 29, 2009·Chemical Biology & Drug Design·Peng XuYu-Liang Wang
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·A PijpersA S Van Miert
Jun 20, 2020·The Veterinary Journal·Dominiek MaesAnne V Gautier-Bouchardon

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