The synergistic anti-tumor effect of schisandrin B and apatinib

Journal of Asian Natural Products Research
Ya-Jing LiZhan-Jun Dong

Abstract

The synergistic anti-tumor effect of schisandrin B (Sch.B) and apatinib was investigated in vitro. The CCK-8 assay revealed that Sch.B enhanced the inhibition of apatinib on cell proliferation by arresting cell cycle in G0/G1 phase. Sch.B also potentiated the suppression of apatinib on cell migration and invasion, by means of wound-healing and transwell invasion assay. Flow cytometry results showed that Sch.B enhanced apoptosis induced by apatinib. The results were confirmed by western blot analysis of the proteins MMP-9, and Bax caspase-9, and -12. These results suggest that combining apatinib and Sch.B is an effective therapeutic strategy for preventing GC progression. [Formula: see text].

References

Dec 29, 2007·World Journal of Gastroenterology : WJG·Xiao-Ni LiuLi Li
Apr 13, 2011·Trends in Molecular Medicine·Pipsa SaharinenKari Alitalo
Jul 16, 2011·Annual Review of Cell and Developmental Biology·Alicia S Chung, Napoleone Ferrara
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin LiHao Yu
Apr 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun PeiBaohui Han
Aug 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hong JianShun Lu
Aug 29, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shan-Shan XiangYing-Bin Liu
Aug 19, 2015·Biochimica Et Biophysica Acta·Saverio CandidoJames A McCubrey
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan JiangChang Liu
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jiexia ZhangWeiqiang Yin
Oct 9, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kazuto HaradaJaffer A Ajani
Sep 9, 2018·Toxicology and Applied Pharmacology·Xuanxuan DaiGuang Liang
Dec 7, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski

❮ Previous
Next ❯

Citations

Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
scraping
electrophoresis

Software Mentioned

ImageJ Plus

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis