The synergistic effects of Chinese herb and injectable calcium silicate/β-tricalcium phosphate composite on an osteogenic accelerator in vitro

Journal of Materials Science. Materials in Medicine
Ming-Hsien HuangMing-You Shie

Abstract

This study investigates the physicochemical and biological effects of traditional Chinese medicines on the β-tricalcium phosphate (β-TCP)/calcium silicate (CS) composites of bone cells using human dental pulp cell. CS is an osteoconductive and bioactive material. For this research we have combined β-TCP and CS and check its effectiveness, a series of β-TCP/CS composites with different ratios of Xu Duan (XD) were prepared to make new bioactive and biodegradable biocomposites for bone repair. XD has been used in Traditional Chinese Medicine for hundreds of years as an antiosteoporosis, tonic and antiaging agent for the therapy of low back pain, traumatic hematoma, threatened abortion and bone fractures. Formation of bone-like apatite, the diametral tensile strength, and weight loss of composites were considered before and after immersion in simulated body fluid (SBF). In addition, we also examined the effects of XD released from β-TCP/CS composites and in vitro human dental pulp cell (hDPCs) and studied its behavior. The results show the XD-contained paste did not give any demixing when the weight ratio of XD increased to 5-10 % due to the filter-pressing effect during extrusion through the syringe. After immersion in SBF, the mi...Continue Reading

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Citations

Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Ming-You ShieYi-Wen Chen
Dec 13, 2016·Journal of Endodontics·Ching-Yuang HuangMing-You Shie
Nov 7, 2015·Journal of Materials Science. Materials in Medicine·Ming-Gene TuMing-You Shie
Dec 29, 2017·Journal of Materials Science. Materials in Medicine·Yen-Hong LinMing-You Shie
Jul 29, 2021·Biomedical Physics & Engineering Express·George Gonçalves Dos SantosFabiana Paim Rosa

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