The synergistic impact of nonalcoholic fatty liver disease and metabolic syndrome on subclinical atherosclerosis

Clinical Endocrinology
Ho Cheol HongKyung Mook Choi

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a well-known contributor for the development of cardiovascular disease (CVD). We examined the influence of NAFLD and metabolic syndrome (MetS) on markers of subclinical atherosclerosis, including carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV) and ankle-brachial pressure index (ABI), after adjusting for cardiometabolic risk factors. A cross-sectional study. The association between NAFLD, MetS and markers of subclinical atherosclerosis was assessed in 955 participants without CVD using multiple logistic regression analysis after adjusting for multiple cardiometabolic risk variables. After adjusting for age and sex, CIMT and baPWV were found to be significantly correlated with multiple cardiometabolic risk variables, whereas ABI was only associated with obesity parameters. The prevalence of NAFLD differed significantly according to the presence of subclinical atherosclerosis as defined by both CIMT and baPWV (P = 0·004 and P = 0·007, respectively). After adjusting for potential confounding factors, NAFLD or MetS was not associated with subclinical atherosclerosis as defined by CIMT and baPWV. However, individuals with both NAFLD and MetS had a significa...Continue Reading

References

Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaYoshio Yamamoto
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Angel BreaEmilio Ros
Mar 29, 2005·World Journal of Gastroenterology : WJG·Henry VolzkeUlrich John
Nov 17, 2005·Annals of Internal Medicine·Masahide HamaguchiKazunori Ida
Oct 16, 2008·The American Journal of Gastroenterology·Ryan L McKimmieLynne E Wagenknecht
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Jean Michel PetitBruno Verges
Dec 17, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cecilia SöderbergRolf Hultcrantz
May 13, 2010·Digestive Diseases·Gianluca Perseghin
May 15, 2010·Journal of Hypertension·Paolo SalviPaolo Pazzi
Oct 27, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V PrimeauR Rabasa-Lhoret
Jul 17, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C CatenaF Fallo
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Yun HuangGuang Ning
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Tae Nyun KimKyung Mook Choi
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rae-Chi HuangLeon A Adams
Oct 14, 2014·World Journal of Gastroenterology : WJG·Silvia FargionAnna Ludovica Fracanzani
Jan 7, 2015·Endocrinology and Metabolism·Mee Kyoung KimUNKNOWN Korean Society for the Study of Obesity

❮ Previous
Next ❯

Citations

Jan 27, 2016·Digestive Diseases and Sciences·Alessandro MantovaniGiovanni Targher
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jun 22, 2018·Journal of Complementary & Integrative Medicine·Busisani W LembedeEliton Chivandi
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 25, 2019·International Journal of Endocrinology·Hye Soo ChungKyung Mook Choi
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.