The synergistic use of computation, chemistry and biology to discover novel peptide-based drugs: the time is right

Current Pharmaceutical Design
J Audie, C Boyd

Abstract

The case for peptide-based drugs is compelling. Due to their chemical, physical and conformational diversity, and relatively unproblematic toxicity and immunogenicity, peptides represent excellent starting material for drug discovery. Nature has solved many physiological and pharmacological problems through the use of peptides, polypeptides and proteins. If nature could solve such a diversity of challenging biological problems through the use of peptides, it seems reasonable to infer that human ingenuity will prove even more successful. And this, indeed, appears to be the case, as a number of scientific and methodological advances are making peptides and peptide-based compounds ever more promising pharmacological agents. Chief among these advances are powerful chemical and biological screening technologies for lead identification and optimization, methods for enhancing peptide in vivo stability, bioavailability and cell-permeability, and new delivery technologies. Other advances include the development and experimental validation of robust computational methods for peptide lead identification and optimization. Finally, scientific analysis, biology and chemistry indicate the prospect of designing relatively small peptides to the...Continue Reading

Citations

Feb 10, 2012·Journal of Natural Products·David J Newman, Gordon M Cragg
Aug 25, 2012·Future Medicinal Chemistry·Joseph Audie, Jon Swanson
Mar 1, 2014·Future Medicinal Chemistry·Jan A HissGisbert Schneider
Nov 8, 2014·Database : the Journal of Biological Databases and Curation·Julien ReyPierre Tuffery
Apr 12, 2011·Neuropeptides·Luciana Malavolta, Francisco Romero Cabral
Feb 15, 2011·Trends in Biotechnology·Peter VanheeJoost Schymkowitz
Dec 21, 2012·Chemical Biology & Drug Design·Leah N Makley, Jason E Gestwicki
Feb 6, 2020·PloS One·Rana Adnan TahirSheikh Arslan Sehgal
Feb 8, 2016·ACS Biomaterials Science & Engineering·Prathamesh M KharkarApril M Kloxin
Dec 21, 2021·EMBO Molecular Medicine·Shunyi ZhuJan Tytgat

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