The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

Annals of the Rheumatic Diseases
F PesslerH R Schumacher

Abstract

To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A). Synovial membranes from patients with femur fracture, avascular necrosis of the femur, plica syndrome, and meniscus and/or ligament injury (n = 23); rheumatoid arthritis (n = 28); osteoarthritis (OA; n = 25); and from normal controls (n = 10) were assessed by light microscopy, a histological synovitis score, immunostaining for CD3, CD20, CD38, CD68, Ki-67 and von Willebrand factor, and with an immunohistochemical inflammation score. Orth. A histology varied between normal and markedly inflamed. Predominant abnormalities were mild lining hyperplasia, scattered inflammatory cells and small perivascular infiltrates. The synovitis score classified Orth. A as "mild synovitis". Inflammatory cells occurred frequently: CD68+ cells in 100% of Orth. A specimens; CD3+, 91%; CD38+, 70%; and CD20+, 39%. Orth. A had 36% greater lining thickness (p = 0.04), 40% higher vascular density (p = 0.009) and 51.3-fold higher CD38+ cell density (p = 0.02) than normal controls; and 60% fewer subintimal Ki-67+ cells (p = 0.003), 42% fewer CD68+ lining cells (p<0.01) and 40% fewer subintimal CD68+ cells (p<0.01) than OA. The immunohistochem...Continue Reading

Citations

Jun 16, 2012·Zeitschrift für Rheumatologie·V KrennC Dierkes
Feb 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Carla R Scanzello
Mar 26, 2014·Clinical Orthopaedics and Related Research·Wenzel WaldsteinFriedrich Boettner
Jun 3, 2014·Journal of Medical Case Reports·Priya KulkarniAbhay Harsulkar
Oct 28, 2011·The Veterinary Quarterly·Janny C de Grauw
Oct 21, 2015·Scandinavian Journal of Rheumatology·A S SiebuhrM A Karsdal
May 27, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stefan KluzekJulia Newton
Feb 11, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Cecilie Kjelgaard-PetersenAnne-Christine Bay-Jensen
Jan 26, 2016·Biochemical and Biophysical Research Communications·Yusuke MatsuoHitoshi Kohsaka
Feb 5, 2010·Best Practice & Research. Clinical Rheumatology·Mukundan AtturSteven B Abramson
May 7, 2010·Clinical and Translational Science·Bradley J RabquerAlisa E Koch
May 4, 2011·Arthritis and Rheumatism·Tobias B KurthCosimo De Bari
Mar 7, 2012·Arthritis and Rheumatism·Richard F LoeserMary B Goldring
Sep 11, 2012·Osteoarthritis and Cartilage·B J E de Lange-BrokaarM Kloppenburg
Feb 8, 2011·Fertility and Sterility·Roberta CoronaPhilippe Robert Koninckx
Jun 22, 2014·Tissue Engineering. Part B, Reviews·Niamh FahyJ Mary Murphy
Nov 29, 2014·Current Osteoporosis Reports·Lara LongobardiAnna Spagnoli
Aug 20, 2016·Nature Reviews. Rheumatology·William H RobinsonJeremy Sokolove
Nov 3, 2015·Osteoarthritis and Cartilage·J LieberthalC R Scanzello
Jan 5, 2017·Journal of Paediatrics and Child Health·Vanessa CecchinFrancesco Zulian
Dec 15, 2016·Annals of the Rheumatic Diseases·Harini RaghuWilliam H Robinson
Oct 27, 2017·Modern Rheumatology·Yusuke MatsuoHitoshi Kohsaka
Apr 27, 2018·Connective Tissue Research·Elisa BelluzziMarta Favero
Feb 4, 2014·Therapeutic Advances in Musculoskeletal Disease·Yves HenrotinCecile Lambert
Jun 3, 2010·The Journal of Rheumatology·Alexis OgdieFrank Pessler
Oct 17, 2016·The Journal of Rheumatology·Aurélie NajmBenoît Le Goff
Dec 13, 2019·Diabetes/metabolism Research and Reviews·Francesca CannataPaolo Pozzilli
Nov 18, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A OgdieFrank Pessler
Dec 19, 2018·Der Schmerz·T A NeesB Moradi

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