The synthesis and biological evaluation of a range of novel functionalized benzopyrans as potential potassium channel activators

Bioorganic & Medicinal Chemistry Letters
Elizabeth TyrrellAlistair Mann

Abstract

A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.

Citations

May 11, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Taeho Lee, Young-Dae Gong

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